Uso de preditores de risco em idosos no Brasil: uma revisão integrativa / Use of risk predictors in the elderly in Brazil: an integrative review / Uso de predictores de riesgo en mayores en Brasil: una revisión integradora

O processo de envelhecimento da população brasileira criou a necessidade de modificar a dinâmica do atendimento aos idosos nos serviços de saúde, organizando-a conforme critérios que indicam gravidade. Nesse sentido, essa revisão integrativa tem como objetivo descrever, analisar e relacionar o uso de preditores de risco no Brasil, aplicados em idosos com 60 anos ou mais, visando à efetividade e aplicabilidade dos índices.

The aging process of the Brazilian population created a need to change the dynamics of the attendance of elderly in health services, organizing it according the criteria that indicate severity. In this sense, this integrative review aimed to describe, analyze and to relate the use of risk predictors in Brazil, applied in the elderly aged 60 or more, aiming the effectiveness and applicability of the index.

El proceso de envejecimiento de la población brasileña creó la necesidad de cambiar la dinámica de atención de mayores en servicios de salud, organizándola según los criterios que indican severidad. En este sentido, esta revisión integrativa tuvo como objetivo describir, analizar y relacionar el uso de predictores de riesgo en Brasil, aplicado en ancianos de 60 años o más, con el objetivo de la efectividad y aplicabilidad del índice.

Association of HLA antigens and BCR-ABL transcripts in leukemia patients with the Philadelphia chromosome

OBJECTIVE: This study aimed to verify the association between human leukocyte antigens and the bcr-abl fusion protein resulting from t(9;22)(q34;q11) in chronic leukemia myeloid and acute lymphoblastic leukemia patients. METHODS: Forty-seven bcr-abl positive individuals were evaluated. Typing was performed bymicrolymphocytotoxicity and molecular biological methods (human leukocyte antigens Class I and Class II). A control group was obtained from the data of potential bone marrow donors registered in the Brazilian Bone Marrow Donor Registry (REDOME). RESULTS: Positive associations with HLA-A25 and HLA-B18 were found for the b2a2 transcript, as well as a tendency towards a positive association with HLA-B40 and a negative association with HLA-A68. The b3a2 transcript showed positive associations with HLA-B40 and HLA-DRB1*3. CONCLUSION: The negative association between human leukocyte antigens and the BCR-ABL transcript suggests that binding and presentation of peptides derived from the chimeric protein are effective to increase a cytotoxic T lymphocyte response appropriate for the destruction of leukemic cells.