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Indian J Biochem Biophys ; 1993 Dec; 30(6): 376-81
Artigo em Inglês | IMSEAR | ID: sea-27343

RESUMO

The ability of purified plasma membrane glycoconjugates to inhibit the EDTA-resistant agglutination between aggregation-stage cells of Dictyostelium discoideum has suggested that receptor binding of these glycoconjugates provides a basis for cell-cell cohesion during aggregation. This has been tested by analysis of a series of mutants with different defects in the assembly of N-linked oligosaccharides. Mutant HL241 lacks outer branch components of N-linked oligosaccharides and fails to aggregate or express EDTA-resistant cohesion. HL244 makes unsulphated but otherwise normal N-linked oligosaccharides, generates multiple tips on aggregated cell mounds in some clones, and shows abnormally strong EDTA-resistant cohesion. Two mutants that are temperature-sensitive for complete processing of N-linked oligosaccharides are also temperature-sensitive for expression of both aggregation ability and EDTA-resistant cohesion. A revertant that recovered essentially normal N-linked oligosaccharide processing at the restrictive temperature has also recovered its ability to aggregate and to agglutinate in EDTA.


Assuntos
Aglutinação , Animais , Sequência de Carboidratos , Membrana Celular/fisiologia , Dictyostelium/fisiologia , Glicolipídeos/química , Glicoproteínas de Membrana/química , Lipídeos de Membrana/química , Dados de Sequência Molecular , Oligossacarídeos/química
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