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Journal of Experimental Hematology ; (6): 1050-1055, 2021.
Artigo em Chinês | WPRIM | ID: wpr-888517

RESUMO

OBJECTIVE@#To investigate the effect of sulforaphane (SFN) on G@*METHODS@#KG1a and KG1cells were treated by different concentrations of SFN for 48 h. Flow cytometry (FCM) was used to analyze the phase distribution of cell cycle. High-throughput sequencing was used to detect the effect of SFN on the expression of cell cycle related genes in KG1a cells. The mRNA expression of P53, P21, CDC2 and CyclinB1 were detected by qPCR. The protein expression of P53, CDC2, P-CDC2 and CyclinB1 were detected by Western blot.@*RESULTS@#Cells in the G@*CONCLUSION@#SFN induces leukemia cells to block in G


Assuntos
Humanos , Ciclo Celular , Isotiocianatos/farmacologia , Leucemia Mieloide Aguda , Mitose , Sulfóxidos
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