RESUMO
Abstract Background Skin cancer is the most frequent cancer worldwide and the most frequent periocular tumor. Keratinocyte Carcinomas (KC) located in periorificial areas, such as periocular tumors, are considered high-risk tumors. Mohs Micrographic Surgery (MMS) is considered the first line for the treatment of high-risk KC, providing a lower recurrence rate than conventional wide excision. Objective To describe the clinical-pathological features of periocular KC treated with MMS in a tertiary university center in Chile. Methods A single-center, retrospective study of patients with KC located on the periocular area, that underwent MMS between 2017‒2022. MMS details were recorded. Results One hundred thirteen patients with periocular carcinomas were included. The mean age was 59 ± 13 years; 52% were women. The most frequent location was the medial canthus (53%), followed by the lower eyelid (30.1%). The most frequent BCC histology was the nodular variant (59.3%). Regarding MMS, the average number of stages was 1.5 ± 0.7, and 54% of the cases required only 1 stage to achieve clear margins. To date, no recurrence has been reported. Tumors larger than 8.5 mm in largest diameter or 43.5 mm2 were more likely to require complex reconstruction. Study limitations Retrospective design and a relatively low number of patients in the SCC group. Possible selection bias, as larger or more complex cases, may have been referred to oculoplastic surgeons directly. Conclusion The present study confirms the role of MMS for the treatment of periocular KCs. Periocular KCs larger than 8.5 mm might require complex reconstruction. These results can be used to counsel patients during pre-surgical visits.
RESUMO
El complejo linfangioleiomiomatosis (LAM)-esclerosis tuberosa (ET) es una enfermedad rara, con compromiso multisistémico que afecta principalmente pulmón y cerebro. Se presenta el caso de una paciente de 25 años con LAM pulmonar que ingresa a la institución para protocolo de trasplante pulmonar. Durante los estudios de extensión se documenta compromiso extrapulmonar sistémico del complejo LAM-ET. A partir de este caso, se realizó una revisión de la literatura de las manifestaciones radiológicas sistémicas de la enfermedad y las recomendaciones de diagnóstico y manejo de estos pacientes; en especial, las indicaciones y contraindicaciones del trasplante pulmonar.
The lymphangioleiomyomatosis (LAM) - Tuberous Sclerosis (TS) Complex is a rare disease with multisystem involvement affecting mainly lung and brain. We present the case of a 25-year-old female patient with pulmonary LAM. During the work-up studies for the lung transplantation protocol, the systemic extrapulmonary involvement of the LAM-TS complex is documented. From this case, a literature review of the systemic radiological manifestations of the disease and of the diagnosis and management recommendations of these patients was made. Special focus was made on the indications and contraindications of lung transplantation.
Assuntos
Humanos , Esclerose Tuberosa , Transplante , Linfangioleiomiomatose , AngiomiolipomaRESUMO
Abstract The present study is aimed to determine some epidemiological aspects related to homicides committed by hired killers with firearms. We conducted a data collection survey of historical records from the Institute of Legal Medicine and Forensic Sciences. The sample (n = 310) is composed of homicide victims in 2007 in the departments of Atlántico and Magdalena. We found that 93.5 % of the victims were male. Most of the victims (38.7 %) were found in the age range between 21 and 30 years old. A high percentage (32.9 %) of the victims were unmar ried. The most common racial trait was the "mestizo" (94.2 %). A percentage of 48.4 % of the victims had a height between 161 and 170 cms. The days with higher incidence of killings were Mondays (19 %) and Fridays (18.4 %). The places where most of the murders happened were "in public" places with a percentage of 33.2 %. The most common number of bullet impacts was "2" with a 21.3 %. The most common body region impacted was on the head. Finally the paper presents the findings of the study.
Resumen El presente estudio se propuso determinar algunos aspectos epidemiológicos relacionados con los homicidos cometidos por sicarios con arma de fuego. Se realiza una colección de registros históri cos del Instituto de Medicina Legal y Ciencias Forenses. La muestra (n=310) está compuesta por víctimas de homicidio del año 2007 en los departamentos Atlántico y Magdalena. Se encontró que el 93,5 % de las víctimas eran de sexo masculino. La mayoría de las víctimas (38,7 %) se en contraban en el rango de edad de 21 a 30 años. Un alto porcentaje (32,9 %) de las víctimas vivían en unión libre. El rasgo facial más común era el "mestizo" (94,2 %). El 48,4 % de las víctimas me dia entre 161 y 170 centímetros de estatura. Los días con mayor incidencia eran los lunes (19 %) y los viernes (18,4 %). Los lugares descritos como "públicos" fue donde ocurrieron la mayoría de los homicidios con un porcentaje del 33,2 %. "2" fue el número de impactos de bala más común con un 21,3 %. La región corporal que fue impactada con mayor frecuencia se trató del área de la cabeza. Finalmente, el artículo presenta los resultados del estudio.