Gene knockout technology and its application in the study of the relationship between mitochondrial dynamics and insulin resistance / 生物工程学报

Mitochondrial dynamics, the processes of mitochondrial fusion and fission maintain homeostasis, are precisely regulated by fusion/fission-related proteins, and play an important physiological role in mitochondrial metabolism, quality and function. The aberrant changes of these proteins can trigger mitochondrial dynamics imbalance, which cause mitochondrial dysfunctions and result various disease states. This article focuses on gene knockout technology, and reviews the role and application progress of genes encoding for fusion and fission knockout mice in insulin resistance researches, in order to lay a foundation for future studies on signal transduction mechanism of mitochondrial dynamics imbalance in insulin resistance.

A meta-analysis of mindfulness-based stress reduction for improving symptoms of post-traumatic stress disorder / 中国心理卫生杂志

Objective:To systematically examine the efficacy of mindfulness-based stress reduction (MBSR) for post-traumatic stress disorder (PTSD).Methods:A systematic literature search was performed in multiple databases,including Cochrane Library,Pubmed,MEDLINE,Embase,Web of Science,CBM,CNKI,WanFang Database.Paper inclusion criteria were confined to intervention trials of MBSR conducted in patients with PTSD.Revman5.3 and Stata12.0 was used to get pooled results.Results:A total of 8 studies were included,4 randomized controlled trials (including 255 patients with PTSD) and 4 self-controlled studies (including 152 patients with PTSD).Comparing to control groups,MBSR groups resulted in statistically significant improvements on symp toms of PTSD [SMD =-0.53,95 ％ CI(-0.87--0.19),P ＜ 0.05].The symptoms of PTSD after the intervention was improved [SMD =-1.95,95％ CI(-2.84--1.07),P ＜0.01].There was no statistically significant difference between the data of follow-up and post-intervention [SMD =-0.26,95％ CI(-0.77-0.26),P ＞0.05].Contusion:It suggests that the mindfulness-based stress reduction (MBSR) may be effective in reducing symptoms of post-traumatic stress disorder and have stable short-term effects.