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Aim: To evaluate the expression of E-cadherin (E-cad) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Material and Method: Immunohistochemistry was used to detect E-cad expression in 20 cases each of normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma. Statistical Analysis Used: Inferential statistical methods for statistical analysis used were Chi-square test for comparison of the frequency between different severity of dysplasia and OSCC. Results: Upon assessing the expression of E-cad in OED and OSCC, increase in E-cad immunoreactivity was seen in early lesions. However, the expression of E-cad decreased significantly as the grade of dysplasia increased. Conclusion: We observed a significant decrease in E-cad expression from dysplasia to poorly differentiated squamous cell carcinoma suggesting that loss of expression of E-cad is closely related to carcinoma.
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Background: COVID-19 has caused a very high burden of morbidity and mortality across the world, India being also badly affected. The disease has a wide spectrum ranging from asymptomatic to severe illness and death. Research work on the epidemiological and clinical profile of patients is scarce in India. Objectives: This study was conducted to know the clinicoepidemiological profile of indoor hospitalized Covid 19 patients. Methods: a retrospective analysis (record based) conducted at a designated COVID tertiary care center. Study period-1st August 2020 to 31st October 2020. Study Unit- Laboratory confirmed COVID 19 patients admitted in the hospital. Sample size- All the 894 patients with complete record were included in the study. Results: The mean age was 47.68± 17.62 years. Around 14.1% of the population was asymptomatic. 75.7% were classified as having a mild disease. The cure rate was 82.9% and deaths were reported in 9.4%. More than half of the population was having at-least one co-morbidity. Conclusions: Our findings were similar to findings observed in other studies. A positive significant correlation was noticed between age, duration, clinical severity and outcome of patient. The clinical severity was also found to be associated with age, duration of symptoms and outcome of patient.
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Background & objectives: Psoriasis is a chronic inflammatory skin disease with unknown aetiology. So far studies have confirmed that interleukins, pro-inflammatory factors and T-cell activation play major role in the development of disease. Interleukin-17 (IL-17) a T helper inflammatory cytokine, was found to be positively correlated with severity of psoriasis. However, the specific mechanism has not been clarified. IL-17A and IL-17F are group members of IL17 family cytokines and found to be located adjacent to one another on the same human chromosome, 6p12. The present study was designed to identify the association between IL-17A and IL-17F gene polymorphism with susceptibility of psoriasis in north Indian population. Methods: A total of 166 psoriasis patients and 150 healthy controls were genotyped for IL-17A and IL-17F gene polymorphism by amplification refractory mutation system-polymerase chain reaction method. One single nucleotide polymorphism (SNP) was analysed in IL-17A (rs10484879) and one SNP in IL-17F (rs763780) to look for an association with psoriasis. Results: Our study indicated decreased frequency of IL-17A (rs10484879) G allele (51.8 vs. 65.0%), and IL-17F (rs763780) C allele (36.5 vs. 45.7%) in psoriatic patients as compared to healthy controls. Interpretation & conclusions: The present findings suggest that IL-17A (rs10484879) G/T and IL-17F (rs763780) C/T gene polymorphisms may contribute in pathogenesis of psoriasis. Further studies need to be done to confirm these findings.
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A case of pyoderma gangrenosum is reported in a 52-year-old man who had skin lesions without any association. On investigation urinary tract infection was detected. Treatment of UTI led to spontaneous healing of the lesions in short period thus avoiding the need of oral corticosteroids.
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The problem of febrile convulsions in the infant and the young child has been reviewed from the aspect of potential neurologic sequellae, the prognosis for recurrence of seizures and the emphasis on the management of the condition during an acute episode. Because of the potential hazards of recurrent attacks, the continuous administration of antiepileptic drugs is recom-mended, in all cases of febrile convulsions for a period of three to four year.