RESUMO
Multidrug resistance impacts negatively upon the curative effect of chemotherapy and prognosis in colorectal cancer. There is a growing body of studies trying to develop drugs to overcome multidrug resistance against its common targets, including ATP-binding cassette proteins, metabolic enzymes, apoptotic genes, signaling pathways and genetic material, among which P-glycoprotein inhibitors and drugs disrupting DNA are deeply developed. Developing new inhibitors or combining existing inhibitors with conventional treatment are hopeful ways to overcome multidrug resistance in colorectal cancer.
RESUMO
More and more scholars have accepted the hypothesis of tumor stem cells after successful separation of tumor stem cells from tumor tissues. Tumor stem cells are considered as origins of recurrence and metastasis of malignant tumors. Studying all kinds of tumor stem cell markers and identifying them, clarifying the mechanisms of their resistance to chemotherapy and radiotherapy will bring new hope to conquer carcinoma.