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Journal of Southern Medical University ; (12): 2693-2695, 2010.
Artigo em Chinês | WPRIM | ID: wpr-267705

RESUMO

<p><b>OBJECTIVE</b>To investigate the expression of c-myb in reflux esophagitis, Barrett esophagus and esophageal adenocarcinoma.</p><p><b>METHODS</b>The expression levels of c-myb in the esophageal mucosa tissue of patients with reflux esophagitis, Barrett esophagus and esophageal adenocarcinoma were detected by real-time fluorescent quantitative RT-PCR.</p><p><b>RESULTS</b>The expression levels of c-myb mRNA in Barrett esophagus and esophageal adenocarcinoma tissues was significantly higher than that in normal and reflux esophagitis esophageal tissue (P<0.05 or 0.01), and increased progressively with the development of reflux esophagitis into Barrett esophagus and esophageal adenocarcinoma.</p><p><b>CONCLUSIONS</b>The expression level of c-myb mRNA is closely related with the development of Barrett esophagus and esophageal adenocarcinoma, and may be used as a valuable index for monitoring the early onset and intervention of Barrett esophagus and esophageal adenocarcinoma.</p>


Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adenocarcinoma , Metabolismo , Patologia , Esôfago de Barrett , Metabolismo , Patologia , Neoplasias Esofágicas , Metabolismo , Patologia , Esofagite Péptica , Metabolismo , Patologia , Mucosa , Metabolismo , Proteínas Proto-Oncogênicas c-myb , Metabolismo
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