Comparison of the predictive value of four critical scoring systems in predicting the prognosis of children with sepsis / 中国小儿急救医学

Objective:To analyze the predictive value of four scoring systems,Pediatric Clinical Illness Score (PCIS),Pediatric Logistic Organ Dysfunction Score 2 (PELOD-2),Pediatric Risk of Mortality Ⅲ (PRISM Ⅲ),and Pediatric Sequential Organ Failure Assessment (pSOFA),in the severity and prognosis in pediatric sepsis.Methods:The medical records of 159 children with sepsis who admitted to PICU at the First Hospital of Jilin University between August 2015 and December 2020 were retrospectively analyzed.The PCIS,PELOD-2,PRISM Ⅲ and pSOFA scores were calculated according to the worst value of each index within 24 h of admission.The children were divided into survival group and death group based on clinical outcomes during hospitalization.The children were stratified according to the severity of sepsis into sepsis (no organ dysfunction) group ( n=18) and severe sepsis group ( n=141).The receiver operator characteristic (ROC) curve was used to evaluate the value of PCIS,PELOD-2,PRISM Ⅲ and pSOFA scores in predicting the severity and prognosis in pediatric sepsis. Results:There were 97 (61.01%) cases in the survival group and 62(38.99%) cases in the death group.There were 141(88.68%) children with severe sepsis.The areas under curve (AUCs) of PCIS,PELOD-2,PRISM Ⅲ and pSOFA scores for predicting severe sepsis in children with sepsis were 0.869,0.875,0.672 and 0.933,respectively (all P <0.05).The AUCs of PCIS,PELOD-2,PRISM Ⅲ and pSOFA scores for predicting the death of children with sepsis in PICU were 0.687,0.697,0.716 and 0.656,respectively (all P<0.05). Conclusion:Among the four scoring systems,the pSOFA scoring system had the highest predictive power for the severity of sepsis.The PRISM Ⅲ score had higher value in assessing the risk of death in all patients with sepsis.

Laboratory detection of mycoplasma pneumoniae infections / 中国小儿急救医学

Detection of mycoplasma pneumoniae infections is essential to diagnosis and initiate appropriate antibiotic therapy.Laboratory detection of mycoplasma pneumoniae includes culture, nonamplified antigen detection, molecular-based methods(detection of DNA and RNA), serology and other new diagnostic methods.These relative methods, advantages, limitations and clinical utility are summarized in this review.

Research on effective connectivity of intracerebral electroencephalogram based on Wiener-Granger Causality Index modified by generalized Akaike's Information Criterion / 生物医学工程学杂志

The objective is to deal with brain effective connectivity among epilepsy electroencephalogram (EEG) signals recorded by use of depth electrodes in the cerebral cortex of patients suffering from refractory epilepsy during their epileptic seizures. The Wiener-Granger Causality Index (WGCI) is a well-known effective measure that can be useful to detect causal relations of interdependence in these kinds of EEG signals. It is based on the linear autoregressive model, and the issue of the estimation of the model parameters plays an important role in the calculation accuracy and robustness of WGCI to do research on brain effective connectivity. Focusing on this issue, a modified Akaike's information criterion algorithm is introduced in the computation of the WGCI to estimate the orders involved in the underlying models and in order to advance the performance of WGCI to detect brain effective connectivity. Experimental results support the interesting performance of the proposed algorithm to characterize the information flow both in a linear stochastic system and a physiology-based model.

Survey and analysis of knowledge, attitude and practice of physical restraints on ICU nurses in third-grade class-A hospitals in Urumqi / 中国实用护理杂志

Objective To explore the knowledge, attitude and practice (KAP) about physical restraints among critical nurses in Urumqi, so as to provide basis for further intervention. Methods Totally 660 critical nurses in 21 ICUs from four integrated third-grade class-A hospitals and two third-grade class-A specialized subject hospitals of Urumqi were selected using cluster random sampling and investigated on KAP about physical restraints. Results The average score of physical restraints knowledge was 3.53 ± 1.77. The total awareness rate was 50.43％. The average score of physical restraints attitude was 78.43±11.05. The practice of physical restraints turned out to be at middle level. The average score of physical restraints practice was 128.11 ± 9.60. Conclusions ICU nurses in Urumqi third-grade class-A hospitals generally lack of physical restraints knowledge, however, they were active in physical restraints attitude and practice, there is still some shortcomings, so it is advisable for relevant departments taking targeted intervention measures to improve ICU nurses cognition of physical restraints, then meliorate their physical restraints practice.

Effect of Ginsenoside Re and Rb3 on mice with viral myocarditis / 中国小儿急救医学

Objective To study the role of Ginsenoside Re and Rb3 on mice with viral myocarditis (VMC) and explore the mechanisms. Methods BALB/C mice were infected by coxsackievirus B3 ( CVB3) to establish VMC model. The mice were divided into control group,virus group and Ginsenoside Re and Rb3 treatment group(treatment group). On day 5,day 10,day 20 after infection,the level of serum crea-tine phosphokinase-MB( CK-MB) was detected. Then myocardial sections stained with Masson′s trichrome were used to observe the distribution of mice myocardial collagen fibers, quantify collagen volume fraction (CVF),and detect the levels of superoxide dismutase(SOD). Results (1)The level of CK-MB peaked on day 5,and decreased afterwards[day 5:(463. 68 ± 47. 62) U/L; day 10:(588. 81 ± 56. 09) U/L; day 20:(340. 48 ± 58. 22) U/L,respectively]. While the levels of CK-MB in treatment group were lower than those in virus group[day 5:(378. 69 ± 56. 02) U/L;day 10:(452. 56 ± 67. 78) U/L; day 20:(327. 13 ± 47. 20) U/L,respectively] in the same point. There were significant differences between groups on day 5 and day 10 (P<0. 01). (2) In viral group,the blue staining degree gradually increased with time in myocardial sections stained with Masson′s trichrome,especially in myocardial necrosis area. Compared with treatment group,CVF increased significantly in virus group on day 10 and day 20 ( day 10:6. 52% ± 2. 34% vs. 8. 94% ± 1. 67%;day 20:7. 00% ± 1. 53% vs. 10. 46% ± 1. 74%,P<0. 01). The levels of SOD in myocardial sections in virus group were lower than those of control group[day 5:(48. 83 ± 17. 74) U/L;day 10:(61. 41 ± 14. 58) U/L;day 20:(66. 26 ± 18. 97) U/L,respectively,P<0. 05],but in treatment group,the level of SOD could beimprovedsignificantly[day5:(72. 07 ±24. 85)U/L;day10:(83. 22 ±19. 52)U/L;day20:(92. 00 ± 20. 46) U/L, respectively, P < 0. 05]. Conclusion Because of the inhibition of oxygen radicals and oxidative stress, Ginsenoside Re and Rb3 can protect myocardial tissue. Ginsenoside Re and Rb3 can effectively reduce the extent of myocardial fibrosis. The mechanism may be related with the reduced peroxide level in vivo.

Clinical effects of bird's nest nursing on premature infants / 中国实用护理杂志

Objective To study the effect of bird's nest nursing on the vital signs,gastroenteric function,body weight and growth of premature infants.Methods 456 cases of premature infants were divided into the warm box group and the bird's nest group randomly according to odd and even number of birth,namely 228 cases in each group.The warm box group adopted routine nursing care.The bird's nest group adopted routine nursing care and bird's nest nursing in the mean time,namely the bird's nest wag put into the warm box,the premature infants slept in the pre-heated bird's nest.The condition of the two groups Was compared.Results On the first day of birth,there were no statistical difference(P＞0.05)between the two groups in respiration,heart rate,milk amount and body weight.On the seventh and fourteenth day,respiration and heart rate were stable and milk amount and body weight increased rapidly in bird's nest group.There Was statistical difference(P＜0.05)between the two groups.In bird's nest group,the premature had long sleeping time and body temperature-fluctuation was reduced.There was statistical differencere(P＜0.01)between the two groups.Conclusions After the bird's nest was used in premature care,diseases were recovered rapidly,hospitalization days were shortened and it was beneficial to the development of intelligence and body and mind of the premature infants.