Evaluation of antiulcer activity of the methanolic extract of the flowers of pterospermum acerifolium [L] willd

In respect of the traditional uses of medicinal plants in the treatment of various ulcerative lesions; it was revealed that the flowers of Pterospermum acerifolium [L] Willd. were extensively used in folklore medicine to treat ulcerative lesions, tumors, diabetes and inflammation. So far our knowledge is concerned; the flowers were not yet scientifically evaluated for their antiulcer activity. The present study was carried out with the methanolic extract of the flowers to evaluate its antiulcer activity on aspirin and pylorus ligation-induced gastric lesion in Wistar albino rats. Methanolic extracts of flowers of Pterospermum acerifolium were suspended in 2%v/v of Tween 80, lOOmg/kg and 150mg/kg of methanolic extracts were administered orally to rats of different groups. Ranitidine at the dose level of 20 mg/kg was used as a standard for both aspirin [150 mg/kg, p.o.]-induced and pylorus ligated gastric ulcer models. The gastric content was collected and the volume was measured. The ulcerative index was determined by examining the inner lining of each stomach and was supplemented by the observation of histopathological changes such as congestion, corrosion, hemorrhage and necrosis. The results showed that the methanolic extract of flowers of Pterospermum acerifolium significantly [P<0.001] reduced the total volume of gastric juice, free and total acidity of gastric secretion when compared with the standard group [Ranitidine]. There was also a significant [P<0.001] reduction in ulcer index as compared to the control group

Anti-ulcer activity of the leaves of toddalia asiatica linn

The anti-ulcer activity of the leaves of Toddalia asiatica [Family: Rutaceae] was studied on albino rats. The anti-ulcer activity of the petroleum ether extract, chloroform extract, ethanol and aqueous extract was evaluated by using pyloric ligation and aspirin-induced ulceration models. In both the models, Ranitidine was used as standard drug for comparison. All the test samples revealed significant anti-ulcer activity except petroleum ether extract in aspirin plus pylorus ligated ulceration model. The order of decreasing ulcer score was found to be aqueous extract < ethanolic extract < chloroform extract < petroleum ether extract. The results indicate that the leaves of Toddalia asiatica are endowed with potential anti-ulcer activity

Hepatoprotective activity of leaves of urtica parviflora roxb

Effects of ethanol and aqueous extracts of the leaves of Urtica parviflora [family Unicaceae] were studied on carbon tetrachloride induced hepatic injury in albino rats. The study revealed that both ethanol and aqueous extracts significantly reduced AST, ALT, alkaline phosphatase and total bilirubin levels. The extracts further decreased total leukocyte count. The livers of both extract treated groups showed microfatty changes with a dense collection of lymphoid cells suggesting evidence of very little necrosis or degeneration. The test extracts showed approximately normal wet weight of liver and kidneys. The present findings suggest that the leaves of Urtica parviflora possess potential hepatoprotective activity