RESUMO
Four series of new acridine derivatives of anticipated antitumor activity have been designed and synthesized. The first series belongs to 4-substituted phenylhydrazinocarbonylmethyl 9-oxo-9,10-dihydroacridine-4-carboxylate 10a-h. The second series consists of phenylhydrazinocarbonylmethyl 9-[4-substituted phenyl]aminoacridine-4-carboxylate 12a-k, while the third series comprises 4-substituted phenylcarbonylmethyl 9-[4-substituted phenyl]aminoacridine-4-carboxylate 15a-k. The fourth one belongs to phenylcarbamoylmethyl 9-[4-substituted phenyl]aminoacridine-4- carboxylate 17a-j. The chemical structure of synthesized compounds was elucidated by spectral data and elemental analysis. Seventeen selected compounds [10a, 10g, 10h, 12at 12d, 12g, 12h, 12k, 15a, 15c, 15g, 15h, 15k, 17a, 17f, 17g and 17j] were tested against breast cancer cell line [MCF7] and eight compounds [12g, 12h, 12k, 15g, 15h, 17f, 17g, 17j] were found to exhibit significant antitumor activity
Assuntos
AntineoplásicosRESUMO
Nine series of new acridine derivatives of anticipated antineoplastic activity were synthesized. The first series consists of N,N'-1, 2-bis [9-[4-substituted sulfamoylphenyl] amino-acridine-4-carboxamide] ethylenediamine. The second comprises of N,N'-1,4-bis [9-[4- substituted sulfamoylphenyl] aminoacridine-4-carboxamide] phenylenediamine. The third and fourth are 1-[4-substituted sulfamoylphenyl] aminoacridine-4-carboxylic acid [4-substituted sulfamoylphenyl] amide. The fifth and sixth are 9-ox-1-[4-substituted amino sulfamoylphenyl]-9-10- dihydroacridine-4-carboxylic acid [4- substituted sulfamoylphenyl] amide. The seventh is 2-substituted phenyl-2,6-dihydropyrazolo [3,4,5-kl] acridine-5-carboxylic acid [4- substituted sulfamoylphenyl] amide. The eighth is 4-[5-[N'- phenylhydrazinocarbonyl-6H-pyrazolo [3,4,5-kl acridine-2-yl]-N- substituted benzene sulfonamide. The last one belongs to 2- substituted phenyl-2,6-dihydropyrazolo [3,4,5-kl] acridine-5-carboxyli acid [4-substituted sulfamoylphenyl] hydrazide