Study of anti-ulcer activity of hydro-alcoholic extract of leaves of withania somnifera Linn.

Hydro-alcoholic extract [1:1] of leaves of Withania somnifera Linn. [Family: Solanaceae] was investigated for antiulcer and six weeks of sub acute toxicity study in rats. The acute toxicity study as also performed using mice as animal. Screening for the antiulcer activity was assessed on aspirin, indomethacin, ethanol, cold restraint stress and pylorus ligation induced ulcers. The plant extract was also subjected to sub acute toxicity study of six weeks duration in mice using body and organ weight variation test and different hematological and biochemical parameters. The extract was found to possess significant antiulcer activity in all tested models when compared with control [vehicle] and reference standard drugs Cimetidine and Omeprazole. The acute toxicity study of the test extract revealed an increase in WBC count, keeping all other parameters approximately normal

Pharmacognostical studies on abutilon indicum [Linn.] sweet leaves

Abutilon indicum [Linn.] Sweet [Family: Malvaceae] is traditionally used in the indigenous system of medicine and other folklore remedies. The present paper deals with pharmacognostic study of the leaves in a systematic way. These findings will contribute additional information for the authenticity of the plant to the natural herb users and to the future investigators

Anti-ulcer activity of the leaves of toddalia asiatica linn

The anti-ulcer activity of the leaves of Toddalia asiatica [Family: Rutaceae] was studied on albino rats. The anti-ulcer activity of the petroleum ether extract, chloroform extract, ethanol and aqueous extract was evaluated by using pyloric ligation and aspirin-induced ulceration models. In both the models, Ranitidine was used as standard drug for comparison. All the test samples revealed significant anti-ulcer activity except petroleum ether extract in aspirin plus pylorus ligated ulceration model. The order of decreasing ulcer score was found to be aqueous extract < ethanolic extract < chloroform extract < petroleum ether extract. The results indicate that the leaves of Toddalia asiatica are endowed with potential anti-ulcer activity

Hepatoprotective activity of leaves of urtica parviflora roxb

Effects of ethanol and aqueous extracts of the leaves of Urtica parviflora [family Unicaceae] were studied on carbon tetrachloride induced hepatic injury in albino rats. The study revealed that both ethanol and aqueous extracts significantly reduced AST, ALT, alkaline phosphatase and total bilirubin levels. The extracts further decreased total leukocyte count. The livers of both extract treated groups showed microfatty changes with a dense collection of lymphoid cells suggesting evidence of very little necrosis or degeneration. The test extracts showed approximately normal wet weight of liver and kidneys. The present findings suggest that the leaves of Urtica parviflora possess potential hepatoprotective activity

Studies on the antiulcer activity of Mirabilis jalapa Linn

The antiulcer activity of the aerial parts of Mirabilis jalapa Linn. [fam. Nyctaginaceae] was studied on albino rats. The antiulcer activity of the chloroform extract, ethanolic extract and aqueous extract was evaluated by using pyloric ligation models and alcohol induced ulceration model. All the test samples revealed significant antiulcer activity. The order of decreasing ulcer score was found to be aqueous extract < ethanol extract < chloroform extract in all performed models. The results indicate that the aerial parts of Mirabilis jalapa are endowed with potential antiulcer activity

Analgestic and antipyretic activity of fruits of Marynia annua Linn.

The petroleum ether, chloroform, ethanol and aqueous extracts of Martynia annua Linn. [Fam. Martyniaceae] fruits were studied for analgesic activity on Swiss albino mice using Hot Plate and Tail Flick methods. The extracts were also screened for antipyretic activity by brewer's yeast induced hyperpyrexia model on adult wistar rats. The results were compared with diclofenac sodium. All the extracts showed significant analgesic and antipyretic activity when compared to the standard drug with a lone observation that the degree of activity of the petroleum ether and chloroform extracts are better than the ethanol and aqueous extracts. The present findings suggest that the fruits of the plant are endowed with potential analgesic and antipyretic properties