RESUMO
Eosinophilia is most frequently associated with asthma, allergic conditions, and parasitic infestation. Eosinophilia can also be associated with many forms of cancer. However, eosinophilia is infrequently associated with solid tumors. We experienced a 73-year-old-woman with eosinophilia as a manifestation of paraneoplastic syndrome that was combined with non-small-cell lung cancer (NSCLC). Initially, she was diagnosed with idiopathic hypereosinophilic syndrome, but was diagnosed with NSCLC 1 month later. Here, we report this case with a brief review of the literature.
Assuntos
Asma , Carcinoma Pulmonar de Células não Pequenas , Eosinofilia , Síndrome Hipereosinofílica , Pulmão , Neoplasias Pulmonares , Síndromes ParaneoplásicasRESUMO
BACKGROUND: Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) generates inorganic pyrophosphate, a solute that serves as an essential physiological inhibitor of calcification. Inactivating mutations of ENPP1 are associated with generalized calcification in infancy and an increased risk of developing type 2 diabetes mellitus (T2DM). We hypothesized that the ENPP1 K121Q variant may be associated with increased coronary artery calcification in T2DM patients. METHODS: The study subjects were aged 34 to 85 years and showed no evidence of clinical cardiovascular disease prior to recruitment. A total of 140 patients with T2DM were assessed for their coronary artery calcium (CAC) scores and ENPP1 K121Q polymorphisms were identified. RESULTS: The prevalence of subjects carrying the KQ genotype was 12.9% (n = 18). There were no 121QQ homozygotes. Patients with the KQ genotype did not show a significantly higher CAC score (122 vs. 18; P = 0.858). We matched each patient with the KQ genotype to a respective control with the KK genotype by gender, age, and duration of diabetes. When compared to matched controls, we observed no significant difference in CAC score (P = 0.959). CONCLUSIONS: The ENPP1 K121Q polymorphism does not appear to be associated with coronary artery calcification in patients with T2DM.
Assuntos
Idoso , Humanos , Cálcio , Doenças Cardiovasculares , Vasos Coronários , Diabetes Mellitus Tipo 2 , Difosfatos , Genótipo , Homozigoto , Remoção , Diester Fosfórico Hidrolases , Prevalência , PirofosfatasesRESUMO
Exogenous lipid pneumonia is a rare disease resulting from the aspiration or inhalation of vegetable, animal, or mineral oils. In Korea, the most frequently implicated agent is squalen, which can be obtained from shark liver oil. Lipid pneumonia by aspiration of the vegetable oil is very rare. We experienced a 77-year-old man with a history of ingestion of green perilla oil. His clinical course was favorable; after exposure to the oil was stopped, the patient's symptoms improved.
Assuntos
Idoso , Animais , Humanos , Ácido alfa-Linolênico , Lavagem Broncoalveolar , Ingestão de Alimentos , Inalação , Coreia (Geográfico) , Fígado , Óleo Mineral , Perilla , Óleos de Plantas , Pneumonia Lipoide , Doenças Raras , Tubarões , VerdurasRESUMO
Splenic complications may occur during the course of pancreatitis, as the pancreas and spleen lie adjacent to each other. However, splenic complications associated with pancreatitis are rare, including splenic vein thrombosis, arterial pseudoaneurysm, subcapsular splenic hematoma, and splenic rupture. The management for subcapsular splenic hematoma with pancreatitis remains controversial. We report a case of a 51-year-old man with alcoholic pancreatitis and the rare complication of a large subcapsular splenic hematoma, which was managed conservatively with a good outcome.
Assuntos
Humanos , Pessoa de Meia-Idade , Alcoólicos , Falso Aneurisma , Hematoma , Pâncreas , Pancreatite , Pancreatite Alcoólica , Baço , Ruptura Esplênica , Veia Esplênica , TromboseRESUMO
Immune thrombocytopenic purpura (ITP) can be classified as primary or secondary according to the presence of an underlying non-malignant or malignant disorder, including lymphoproliferative disorders. The estimated prevalence of ITP in patients with Hodgkin's lymphoma is about 1%, and its clinical course has been reported in approximately 50 patients. ITP is an unusual and poorly documented complication in patients with non-Hodgkin's lymphoma. Some cases have been described in patients who have undergone high-dose chemotherapy and autologous bone marrow/peripheral blood stem cell transplantation. Rare cases appear to be coincidental. Here, we report on a rare case of a 61-year-old man who had ITP after being in a state of complete remission of non-Hodgkin's lymphoma for about 15 months.