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1.
Ceylon Med J ; 2007 Sep; 52(3): 83-6
Artigo em Inglês | IMSEAR | ID: sea-49254

RESUMO

OBJECTIVES: Primary immune deficiency is relatively rare. Patients present with recurrent or persistent infections or infections with opportunistic pathogens. We investigated patients who presented during the years 2005-7 with recurrent or persistent infections or infections with opportunistic organisms, for underlying immune deficiency. DESIGN: Descriptive study. SETTING: Department of Immunology, Medical Research Institute, Colombo. STUDY POPULATION: 257 patients referred to the Department of Immunology, Medical Research Institute, Colombo, with a history of recurrent infections, for evaluation of possible immune deficiency. MEASUREMENTS: Appropriate evaluation of immunological competence of the humoral and cell mediated immune systems. RESULTS: There were 8 patients with agammaglobulinaemia (X linked agammaglobulinaemia and autosomal recessive agammaglobulinaemia), 2 patients each with ataxia telangiectasia, IgA deficiency and hyper-IgE syndrome, 3 patients with common variable immune deficiency (CVID), and 1 patient each with Griscelli syndrome, hyper-IgM syndrome and X linked severe combined immune deficiency (SCID). CONCLUSIONS: Primary immune deficiency must be included in the evaluation of patients with recurrent infections, and timely intervention can prevent morbidity and mortality.


Assuntos
Ataxia Telangiectasia , Doenças Autoimunes/imunologia , Criança , Pré-Escolar , Imunodeficiência de Variável Comum/imunologia , Feminino , Humanos , Deficiência de IgA , Síndromes de Imunodeficiência/diagnóstico , Lactente , Recém-Nascido , Masculino , Projetos Piloto , Recidiva , Imunodeficiência Combinada Severa/imunologia
2.
Ceylon Med J ; 2006 Dec; 51(4): 149-51
Artigo em Inglês | IMSEAR | ID: sea-47364

RESUMO

Hyper-IgE syndrome, a multi-system disorder affecting dentition, skeletal and immune systems and connective tissues, presents with recurrent infections and dermatitis. We report here the first case in Sri Lanka.


Assuntos
Criança , Humanos , Síndrome de Job/diagnóstico , Masculino , Sri Lanka , Infecções Estafilocócicas , Staphylococcus aureus/isolamento & purificação , Resultado do Tratamento
3.
Ceylon Med J ; 2006 Sep; 51(3): 114-7
Artigo em Inglês | IMSEAR | ID: sea-47476

RESUMO

OBJECTIVE: To determine the prevalence of human papilloma virus (HPV) types 16 and 18 in squamous carcinomas of the cervix in Sri Lanka. DESIGN: Case control study. SETTING: One gynaecological unit at the Cancer Institute, Maharagama, Sri Lanka. PATIENTS: 15 patients with squamous carcinoma of the cervix, and 15 age matched controls with histologically normal cervices. MEASUREMENTS: DNA was extracted from paraffin embedded cervical biopsies. Polymerase chain reaction was performed on extracted DNA employing primers specific for HPV types 16 and 18. RESULTS: HPV 16 DNA was detected in 11 out of 15 cervical cancer biopsies (73.3%), in comparison with 3 out of 15 normal controls (20%). HPV 18 was detected in 3 out of 15 cervical cancer biopsies, but not in a single control biopsy. CONCLUSION: Despite the limited number of cases in this cohort, this study supports the strong association between HPV 16 and squamous cancer of the cervix.


Assuntos
Biópsia , Carcinoma de Células Escamosas/patologia , Estudos de Casos e Controles , DNA Viral/análise , Feminino , Papillomavirus Humano 16/genética , Papillomavirus Humano 18/genética , Humanos , Infecções por Papillomavirus/patologia , Reação em Cadeia da Polimerase , Fatores de Risco , Sri Lanka , Neoplasias do Colo do Útero/patologia
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