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Objective:To study the characteristics and clinical diagnostic value of multiparametric magnetic resonance imaging (mp-MRI) for prostate cancer (PCa).Methods:The clinical data of patients with PCa and benign prostatic hyperplasia (BPH) treated in Qinhuangdao Second Hospital from January 2019 to December 2019 were retrospectively analyzed. They were divided into PCa group and BPH group. T2-weighted imaging (T2WI), diffusion weighted imaging (DWI) and dynamic contrast enhanced (DCE)-MRI were performed respectively. The T2WI image characteristics, peripheral band and transitional band apparent diffusion coefficient (ADC) values and DCE-MRI image types were compared between the two groups. Patients in the two groups were evaluated by Prostate Imaging Reporting and Data System (PI-RADS) v2 Score. Receiver operating characteristic (ROC) curve was used to analyze the value of mp-MRI sequences in the differential diagnosis of PCA and BPH.Results:There were significant differences in image features of T2WI and DWI between PCa group and BPH group; the ADC values of both patients in peripheral zone were significantly higher than those in transition zone (all P<0.05); the ADC values of PCa patients in peripheral zone and transition zone were significantly lower than those of BPH patients (all P<0.05). There were statistically significant differences in the types of DCE-MRI images in PCa and BPH patients ( P<0.05), and the Tmax of PCa patients was significantly lower than that of BPH patients ( P<0.05), while the SImax was significantly higher than that of BPH patients ( P<0.05). PI-RADS v2 Score showed that there were statistically significant differences in the T2WI and DWI scores between PCa patients and BPH patients ( P<0.05), and the positive rates of DCE-MRI in the two groups were 94.00% and 24.00% respectively ( P<0.05). ROC curve analysis showed that the sensitivity of T2WI, DWI, DCE-MRI and combined diagnosis of PCa and BPH were 64.0%, 76.0%, 94.0% and 96.0% respectively, and the specificity were 90.0%, 92.0%, 76.0% and 84.0%. Conclusions:mp-MRI sequences have many differences in PCa and BPH. Combined with RI-RADS v2, it can effectively identify and is of great significance for improving the early diagnosis of PCa.
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Objective:To analyze the diagnosis value of multiparametric magnetic resonance imaging (mpMRI) in prostate cancer, and its relationship with clinicopathological grade.Methods:The clinical data of 50 patients with prostate cancer and 50 patients with benign prostatic hyperplasia from January to May 2019 in Qinhuangdao Second Hospital were retrospectively analyzed. All patients were examined by mpMRI, and the results were assessed by 2 radiologists according to the prostate imaging reporting and data system version 2 (PI-RADS 2). The mpMRI results were compared with Gleason score (GS). The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficiency of mpMRI for prostate cancer.Results:For single sequence of mpMRI, when the cut-off value of DWI sequence was higher than 2 scores, the area under the curve (AUC) in diagnosis of prostate cancer was 0.951, and the sensitivity and specificity were 94.00% and 88.00%, respectively; when the cut-off value of T 2WI sequence was higher than 3 scores, the AUC in diagnosis of prostate cancer was 0.920, and the sensitivity and specificity were 80.00% and 96.00%, respectively; when DEE was positive, the AUC in diagnosis of prostate cancer was 0.810, and the sensitivity and specificity were 94.00% and 68.00%, respectively; when the 3 indexes were combined to diagnose prostate cancer, the AUC was 0.960, and the sensitivity and specificity were 90.00% and 96.00%, respectively. The ADC in patients with GS pathology graded low-risk, intermediate-risk and high-risk prostate cancer was (0.95 ± 0.11), (0.75 ± 0.12) and (0.61 ± 0.13) × 10 -3 mm 2/s, and the maximum tumor diameter was (1.27 ± 0.45), (2.17 ± 0.54) and (2.86 ± 0.63) cm. With the increase of the GS pathological grade, the ADC decreased, the maximum tumor diameter increased, and there were statistical differences ( F = 20.519 and 20.396, P<0.01). Spearman correlation analysis result showed that GS had negative correlation with ADC ( r = - 0.765, P<0.01), and positive correlation with the maximum tumor diameter ( r = 0.413, P<0.01). Conclusions:The diagnostic efficiency of mpMRI PI-RADS 2 for prostate cancer is relatively higher. ADC is negatively correlated with GS pathological grade, and the maximum tumor diameter is positively correlated with GS pathological grade, which provides a basis for preoperative diagnosis of prostate cancer.
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Objective:To explore application of multi-parameters magnetic resonance imaging(MRI) in diagnosis of prostate cancer patients, and to analyze the relationship between various parameters and expression level of tissue Ki-67.Methods:One hundred patients suspected with prostate cancer who had underwent multi-parameters MRI before surgery from June 2018 to June 2019 in Qinhuangdao Second Hospital were enrolled. Taking preoperative needle biopsy pathology as golden standard, it was confirmed that there were 50 cases with prostate cancer and 50 cases with benign prostatic hyperplasia (BPH). Imaging features were compared between the two groups. The patients with prostate cancer underwent transrectal ultrasound guided perineal prostate biopsy. The expression of Ki-67 in prostate tissue was detected. The relationship between parameters of multi-parameters MRI and expression level of Ki-67 was analyzed.Results:The combination diagnosis of T 2WI sequence, dynamic contrast-enhanced scan and diffusion-weighted imaging showed that there were 55 positive cases and 45 negative cases. The sensitivity and specificity of combined detection for diagnosis of prostate cancer were 92.00% (46/50) and 82.00% (41/50) respectively. Compared with BPH group, ADC and Tmax level in prostate cancer group were significantly decreased: (0.67 ± 0.13) × 10 -3 mm 2/s vs. (1.28 ± 0.17) × 10 -3 mm 2/s, [(17.43 ± 2.38) s vs. (22.37 ± 3.61) s, while SImax level was significantly increased: (1.85 ± 0.21)% vs. (1.48 ± 0.17)%, P<0.05. The positive index of Ki-67 in prostate cancer patients was significantly higher than that in BPH patients: (68.15 ± 6.31)% vs. (12.64 ± 2.58)%, P<0.05. The positive expression index of Ki-67 was negatively correlated with ADC ( r=-0.516, P<0.05), while positively correlated with maximum enhancement degree ( r=0.426, P<0.05). Conclusions:Multi-parameters MRI can help distinguish prostate cancer and BPH, which is of relatively higher sensitivity and specificity for diagnosis of prostate cancer. There is certain correlation between MRI findings and Ki67, which can reflect proliferation activity of tumor cells.