1.
Indian J Exp Biol
;
1996 May; 34(5): 403-7
Artigo
em Inglês
| IMSEAR
| ID: sea-62888
RESUMO
Entrapment of 5-hydroxyl-L-tryptophan (HT) in erythrocyte ghost prepared by hypotonic method and high voltage electric discharge method are nearly same. Release of HT with beta-aminoethylisothiuronium bromide hydrobromide (HT + AET) in in vitro system is rapid but only a portion of the entrapped amount is released. Release of HT + AET in serum marginally increases at 2 hr. Compared to release in in vitro medium the release in serum is less. Survival studies with Swiss albino mice indicates that compared to HT alone, the combination of HT + AET shows about 9 times percentage survival. The same combination in the encapsulated form show comparable percentage survival though the amount needed is 1/200th times compared to free form.
Assuntos
Animais , Composição de Medicamentos/métodos , Eletricidade , Membrana Eritrocítica , Masculino , Camundongos , Coelhos , Protetores contra Radiação/administração & dosagem , Serotonina/administração & dosagem , beta-Aminoetil Isotioureia/administração & dosagem
2.
Indian Pediatr
;
1975 Oct; 12(10): 975-81
Artigo
em Inglês
| IMSEAR
| ID: sea-9639