RESUMO
<p><b>OBJECTIVE</b>To study the effects of 1-bromopropane (1-BP) on liver and kidney functions of exposed workers.</p><p><b>METHODS</b>Occupational health situation in three 1-BP plants was investigated. Fifty-four workers from the 1-BP manufacturing line were chose to be contact group, while 42 workers from non-1-BP manufacturing line as control group. All workers underwent questionnaire survey, liver function test as well as kidney function test.</p><p><b>RESULT</b>Working years has no impact on liver and kidney functions of workers from contact group. Compared with the control, liver and kidney functions test of the two groups showed no statistical difference either.</p><p><b>CONCLUSION</b>The present investigation doesn't prove any impact of occupational 1-BP exposure on worker's liver and kidney functions.</p>
Assuntos
Humanos , Hidrocarbonetos Bromados , Toxicidade , Rim , Fígado , Exposição OcupacionalRESUMO
<p><b>OBJECTIVE</b>To investigate the effect of smoking on the microRNAs (miRNAs) expression in pneumoconiosis patients.</p><p><b>METHODS</b>Real-time qPCR was used to measure the expression levels of miR-21, miR-200c, miR-16, miR-204, miR-206, miR-155, let-7g, miR-30b, and miR-192 in 36 non-smoking patients with pneumoconiosis and 38 smoking patients with pneumoconiosis, and the differences in expression levels between the two groups were evaluated by two-independent samples t-test.</p><p><b>RESULTS</b>The expression of miR-192 in serum showed a significant difference between non-smoking and smoking pneumoconiosis patients (P < 0.05), and it decreased gradually in smoking patients with stage I and II pneumoconiosis. In the serum of all pneumoconiosis patients, the expression level of miR-16 was the highest, while the expression level of miR-204 was the lowest.</p><p><b>CONCLUSION</b>Pneumoconiosis patients have differential expression of miRNAs in serum, and smoking has an effect on the miRNAs expression in pneumoconiosis patients.</p>