The anti-hyperglycemic effect of fructus lycii extraction on straptozocine-induced glucose intolerance mice and diabetic mice

Background: Continuation of previous study of screening traditional medicinal plants with anti-diabetic effect, the hypoglycemic effect of glue extracted from Fructus Lycii which was named HPD was study. Objective: to investigate the hypoglycemic effect of HPD on diabetic mice caused by different doses of streptozocine. Subjects and methods: causing diabetes by streptozocine at difference doses was used to collect glucose intolerance mice, mild diabetic mice and severe diabetic mice. The effect of HPD p.o. at several doses was evaluated after 3 days of use. Results: By oral allocation with the dose of 500 and 1.000mg/kg body-weight for 3 days, HPD inhibited increasing blood glucose in streptozocine-induced glucose intolerance mice (intraperitoneal STZ 100 mg/kg). HPD 1000 mg/kg body weight had the potent hypoglycemic effect on streptozocine-induced diabetic mice, reverse the blood glucose self control ability of mild streptozicine-induced diabetic mice (STZ 120 mg/kg), meanwhile can not stop a hyperglycemic effect of high dose of STZ (STZ 180 mg/kg). Conclusion: HPD has the potent anti-hyperglycemic effect on streptozocine -induced diabetic rats. Anti-hyperglycemic of HPD is indirect under present of insulin\r\n', u'\r\n', u'\r\n', u'

Study on hypoglycemic potential of Radix Rhemanniae and Rhizoma Anemanhenae

The hypoglycemic effect of TD-1 - a mixture of EtOH extract from the roots of Rehmannia glutinosa (Scrophulariaceae) and Anemarrhena asphodeloides (Liliaceae) - was investigated in normal Swiss mice. TD-1 (80mg/kg - 160 mg/kg) showed no clear hypoglycemic effect after single oral administration (8 hours, p>0.05). TD-1 (80 mg/kg) reduced the blood glucose of the mice from 142.0 (6.8 mg/dl to 61.2 (3.7 mg/dl 7 hours after single peritoneum injection (p<0.01). The results confirm the roles of mentioned above plants as traditional medicinal plants in diabetic treatment.