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Arab Journal of Pharmaceutical Sciences. 2012; 4 (8): 11-18
em Árabe | IMEMR | ID: emr-163723

RESUMO

Dissolution is very important parameter in releasing of active pharmaceutical ingredient from dosage form, and this directly correlate with absorption process and consequently with bioavailability of oral dosage forms [tablet]. Oxcarbazepine is an oral anticonvulsant, and in this research we work on Invitro comparison of dissolution protiles for two native oxcarbazepine tablet 300 mg products with the same of patented [trileptal[rigstered]], calculating similarity factor f[2] as the base of comparison, the value of similarity factors were for product-A [f[2]=77.1], for product-B [f[2]=51] appear similarity of dissolution profiles of two previous product with the same of patented


Assuntos
Carbamazepina/análogos & derivados , Carbamazepina/administração & dosagem , Anticonvulsivantes/administração & dosagem , Preparações Farmacêuticas , Química Farmacêutica
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