Postpartum hypercalcemia secondary to a neuroendocrine tumor of pancreas; a case report and review of literature

Parathyroid hormone-related protein producing pancreatic neuroendocrine tumors have been infrequently reported. Here-in, we report a case of an Iranian woman who had such a tumor during pregnancy, and gave birth to a female neonate with esophago-tracheal fistula and imperforated anus. Hypercalcemia was diagnosed at postpartum because of elevated serum calcium levels in the neonate and neurologic deterioration of the mother. Extensive literature review revealed 42 cases with pancreatic neuroendocrine tumors and hypercalcaemia. The clinical and laboratory findings of such patients are reviewed in this manuscript

Development of new therapeutic strategies in gynecological cancers in Iran by utilizing xenograft model of ovarian adenocarcinoma

To evaluate the potentiality of OVCAR-3 cell line of ovarian adenocarcinoma as a xenograft model for ovarian adenocarcinoma in nude mice. The cell line isolated from advanced human ovarian adenocarcinoma, were inoculated to eight nude mice and two months later. Established tumors were transferred to pathology laboratory to be prepared by H and E staining and immunohistochemical staining with CA125 antibody. Study of H and E slides showed advanced adenocarcinoma. The CA125 Tumor marker was also positive in tumoral tissue. Established tumors showed excellently the characteristics of ovarian adenocarcinoma. This model can be used to evaluate new treatment strategies