Have magnesium sulfate, acetic acid, meprobamate and fluoxetine an anti-arthrogenic activity?

Atherosclerosis is a progressive inflammatory disorder of the arterial wall that is characterized by focal lipid rich deposits of atheroma with possible correlation with sedative hypnotics in decreasing atherogenesis. This study was performed in Al-Kadhimiya teaching hospital from February 2009 to June 2009 on sixty healthy males who were allocated to six groups. Each group was given one of the following agents: Magnesium sulfate [MgSo4], acetic acid, Meprobamate, Fluoxetine in addition to Simvastatin and water. Clinical manifestations like [arterial blood pressure, radial pulsation], lipid profiles [serum cholesterol, triglycerides, HDL, LDL and VLDL] total free radicals and platelets function tests are the parameters used in this study. All the tested agents reduce both the serum cholesterol concentration and total blood free radicals significantly; also they decrease both platelet count and adhesion test significantly. Both MgSo4 and Meprobamate lowered blood pressure and serum triglyceride concentration significantly, at the same time HDL concentration significantly changed by Fluoxetine when these parameters measured before and after treatment for 15 days. MgSo4, acetic acid, Meprobamate and Fluoxetine were found to have anti-arthrogenic activity and the possibility to be used clinically in atherosclerosis

Hepatoprotective effect of some drugs in experimental model of acute liver injury

Acute liver injury is a clinical condition that results from severe extensive damage of liver tissue associated with Jaundice and it is experimentally induced by hepatotoxic agents like ccl[4]. Thirty five healthy rabbits were involved in the present study. They were allocated to five groups. Each group was given one of the following agents: vitamin E, zinc sulfate, amlodipine besylate, distilled water two hours before administration of ccl[4]. The same doses of the tested agents were continued for two days after ccl[4] administration. The effect of drugs was evaluated at two occasions 24 and 72 hours after ALI induction on the basis of biochemical analysis of liver function tests as well as histopathological examination to the liver of treated animals. All the tested agents produced significant reduction in ALT, AST, ALP, and TSB with a significant elevation of TSP levels as compared with treated control group. The histopathological examination showed clear improvements in the sections of liver tissue that support the effect of these agents on the liver. The study showed that 30% of women were anemic; the effect of anemia on thyroid function was not clear as 98% of the studied women have normal thyroxin and only 1% has low thyroxin level while 1% showed high concentration of thyroxin level. All the tested agents proved to have hepatoprotective effect of varying degree on ALI model

Vasodilators versus lansoprazole in prevention of ethanol induced gastric ulcer

Peptic ulcer is a condition result from imbalance between the erosive effect of acid and pepsin and mucosal defense mechanism in the stomach and may be correlated with vasodilators. Forty two healthy albino male rats weighing [180-200] gram were involved in this study. The animals were allocated to six groups. Each group was given one of the following drugs: Lansoprazole, amlodipine, amiodarone, carvedilol and distilled water as control. After 5 days of treatment with these agents, ethanol 95% was administered orally after one hour of the last dose of these agents. Animal were sacrificed after one hour later. The main parameters used in this study were ulcer preventive index, free radicals, changing of serum electrolytes. Ethanol in high concentrations was found to be highly ulcerogenic agent with ratio of 100% when administered orally in rat The preventive index [PI] of these drugs equal 86.95,96.99and 83.63 for amlodipine, amiodarone andcarvedilol respectively in comparing with lansoprazole 99.09. All the tested drugs and lansoprazole produced highly significant change in free radicals of the gastric tissue decreasing MDA levels andincreasing GSH levels. Some of serum electrolytes were significantly changed by the tested drugs. Amlodipine, amiodarone and carvedilol proved to have gastro-protective activity against ethanol induced gastric ulcer and the possibility to be used for patients with peptic ulcer or cardiovascular problems with peptic ulcer

gastro-protective effect of antioxidants in ethanol induced gastric ulcer

Peptic ulcer is a state that result from imbalance between the corrosive effect of acid and pepsin and mucosal defense mechanism in the stomach and may be correlated with antioxidant agents. Forty two healthy albino male rats weighing [180-200] gram were used in this study. The animals were allocated to six groups. Each group was given one of the following drugs: Lansoprazole, Zinc sulfate, chromium, Beta-carotene and distilled water as control. After 5 days of treatment with these agents, ethanol 95% was administered orally after one hour of the last dose of these agents. Animals were sacrificed after one hour later .The main parameters used in this study were ulcer preventive index, free radicals, changing of serum electrolytes. Ethanol in high concentrations was found to be highly ulcerogenic agent with ratio of 100% when administered orally in rat .The preventive index of these drugs equal 97.35, 59.99 and 87.78 for Zinc sulfate, chromium and Beta-carotene respectively in comparing with lansoprazole 99.09. All the tested agents produced highly significant changes in free radicals of the gastric tissue decreasing MDA levels and increasing GSH levels and many of serum electrolytes were significantly changed by the tested drugs. Zinc sulfate, chromium and Beta-carotene proved to have gastroprotective activity against ethanol induced gastric ulcer and the possibility to be used for patients with peptic ulcer