RESUMO
The influence of the calcium-entry blockers, verapamil, nifedipine and diltiazem on hydrochlorothiazide-induced diuresis was determined in hydrated conscious rats. Nifedipine significantly inhibited hydrochlorothiazide-induced 5-h excreted urine volume and urinary sodium with little effect on potassium excretion. Both verapamil and diltiazem significantly enhanced sodium excretion with no effects on either urine colume or potassium excretion. These results are of interest in view of the current use of nifedipine as an anti-hypertensive agent, alone or in combination with a thiazide diuretic
Assuntos
Ratos , Animais , Feminino , Bloqueadores dos Canais de Cálcio/farmacologia , Diurese/efeitos dos fármacos , Hidroclorotiazida/antagonistas & inibidores , Potássio/urina , Sódio/urinaRESUMO
The effects of the aqueous extract of Astronium urundeuva Engl. on aspirin and restraint plus hustmine-induced ulceration in rats are described. The extract significantly inhibited aspirin-induced gastric lesions as well restraint plus histamine-induced ulceration in rats