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Background:High flow nasal cannula is a newer modality of treatment for hypoxemic respiratory failure. Present study is conducted to evaluate demographic characteristics, co-morbidities and outcome parameters of patients on High flow nasal cannula. Material And Methods:In retrospective observational study all patients on High flow nasal canula with covid-19 were evaluated for demographic characteristics and outcome with comorbidities during study period.Result:Maximum number of patients belongs to age group 51-60 years. Highest mortality was in the age group of 61-70 years.Conclusion:The High flow nasal cannula therapy may provide important newer modality and helpful in patients with respiratory failure.
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Background:Standardized scales for scoring severity of poisoning is need of time in Emergency department(ED)to identify high risk patients for intensive monitoring and treatment before disposal and for compatibility of data. So in this study we try to evaluate utility of Glasgow coma scale (GCS), poisoning severity score (PSS) and Acute physiology and chronic health evaluation II (APACHE II) in estimating clinical severity and prognosis of poisoning patients.Material and methods: A Retrospective observational study was conducted between1stJune 2019 to 28thFebruary 2021 in the Emergency Department of tertiary care teaching hospital, Ahmedabad, India. Data was collected from computerized hospital information system and analysed in CDC software Epi Info (version 7.3.2.1).Results:Out of total 50 patients during study,majority of patients were in age group of 21-30 year (yr)with Male: Female ratio of 1:1. Out of 50 cases, 44 consumed chemical substances, 3 had corrosive and 3 had medication consumption with organophosphates (OP) being most common compound. Mean PSS in expired was significantly high in comparisonof survivors (p value= 0.0118). Present study found significant association between PSS within first 24 hours and GCS of patients pre sented with poisoning with p value 0.0117 (GCS on admission) and 0.0002 (GCS at 24 hr). A statistically significant correlation was found between PSS and APACHE II, with a p value= 0.0242 and also between GCS and APACHE II with a p value= 0.0018 (CI=95%).Conclusion:Both PSS and GCSare effective in predicting Severity and outcome of patients presented with poisoning in ED.GCSis more useful as it is easy to use, does not require any laboratory investigations and less time consuming.
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Background:During this long COVID-19 pandemic outbreak, continuous positive airway pressure (CPAP) and noninvasive ventilation (NIV) are being widely used to treat of NIV in COVID-19 acute respiratory distress syndrome (ARDS) are lacking, and for this reason it is extremely important to accurately determine the outcomes of this strategy. This study aimed to evaluate clinical data and outcomes of NIV in patients with COVID-19 ARDS.Material And Methods:This is retrospective observation study conducted at government hospital during April 2020 to July 2020. The study was approved by local ethical committee.We analyzed patients with the laboratory confirmed case of COVID-19 infection admitted in intensive care unit who require positive pressure ventilation and perfusion which are not able to maintain on simple O2 masks/ nasal cannula /NRBM. Data related to clinical features and co-morbidities were recorded at admission and clinical laboratory data were recorded at start of NIV and respiratory parameter were recorded at the time of admission, start of NIV and at the time of weaning or shift to invasive ventilation.Result:Out of 119 patients 42 patients were successfully weaned off from non invasive ventilation while remaining were shifted to invasive mechanical ventilation. The patients who were shifted to invasive ventilation were all died. Low P/F ratio, high CRP, high D-dimer, high LDH and high ferritin levels were related to conversion to invasive ventilation and high mortality among the group.Conclusion:Although there is a role for non-invasive respiratory therapies in the context of COVID-19 ARF, more research is still needed to define the balance of benefits and risks to patients. Indirectly, non-invasive respiratory therapies may be of particular benefit in reducing the risks to healthcare workers by obviating the need for intubation, a potentially highly infectious procedure.
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Background & Objectives: Out of total 328 antigens recognized by the International Society of Blood Transfusion (ISBT), ABO and RhD antigens are the most important from the transfusion medicine perspective. The present study was conducted with larger sample size than prior studies to determine frequencies of ABO and Rh alleles and obtain distribution of ABO and RhD blood group pattern among blood donors. Methods: A retrospective study was conducted in the Department of IHBT, Civil Hospital, Ahmedabad from October 2007 to September 2012. ABO grouping and RhD typing was done using conventional tube technique on a total of 109771 donors. Commercial anti-sera and in-house prepared cells were used for cell and serum grouping respectively in those tests. Departmental Standard Operating Procedures (SOPs) were followed for each aspect of testing. Observed ABO and RhD antigen frequencies were noted. Bernstein and Hardy-Weinberg equations were applied to determine the allele frequencies of ABO and RhD respectively. Results: Blood group B has the highest prevalence (35.81%) in the population under study followed by O (32.74%), A (22.68%) and AB (8.77%). Female donors comprised only 1.75% of the sample size. Rh D positivity was noted in 94.48% donors. Conclusion: Results obtained were quite similar to prior studies from Ahmedabad with smaller sample size. Remarkable differences were noted as compared with western population. The data generated in the present study combined with several other studies of different geographical region of India has significant implications in inventory management of blood transfusion services.
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Background & objectives: Blood is lifesaving fluid that cannot be created artificially. So, Blood donors are the precious resources. Whole blood donation is generally considered to be a safe procedure but sometimes adverse donor reaction (ADR) may occur. Recognition and evaluation of the so called adverse donor reactions during and after whole blood donation has a great value for improving the supply of the blood donation. The present prospective study was carried out with an aim to estimate the frequency and severity of adverse events occurring in whole blood donors at our Regional Blood Transfusion Centre and to study the effect of entertainment as an anxiolytic on development of ADR. Material and Method:The present prospective study was carried out at the IHBT Department of B.J. Medical College, Civil Hospital Campus, Ahmedabad. The period of the study was 2 years ranging from 1st September, 2009 to 31st October, 2011. A total of 42,684 whole blood donations were accepted during the period either on replacement basis in house in blood bank or on voluntary basis in outdoor blood donation camps. On 22-02-2011 television set with entertaining channels was installed at the donor reception area and phlebotomy room of the blood bank. Result:It was noted that 632 (1.48 %) donors had developed one of ADR. Conclusion: Because of anxiety syndrome, the rate of ADR was very high in first-time donors (3.25 %) as compared to repeat donors. Television set with entertaining channels had anxiolytic effect on the donors and striking decline (0.81 % to 0.45 %) was noted in the adverse reactions in replacement donors at blood bank.
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An open comparative trial was conducted in 58 adult obese patients (Body Mass Index > or = 25 kg/square metre). Group I (n = 27), non-drug, was advised diet (1200-1600 cals) and a brisk walk for 30 minutes. Group II, in addition, received Guggulu (Medohar) 1.5-3 gms/day for 30 days. Mean difference in weight loss between Guggulu and non-drug group was 0.32 kg (ns) on day 15 and 0.58 kg on day 30 (ns). The mean weight reduction in patients (> 90 kgs) was 1.92 kg (ns) and 2.25 kg (ns) higher in Guggulu group. All patients weighing > 90 kg lost weight in Guggulu group whilst 3 in non-drug group did not lose weight. Guggulu was tolerated well. The data from this pilot study suggest a synergistic diet-Guggulu interaction over 30 days in patients weighing > 90 kgs which needs to be confirmed in a large placebo controlled study.