Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Filtrar
Adicionar filtros








Intervalo de ano
1.
Artigo em Inglês | AIM | ID: biblio-1262966

RESUMO

The psychopharmacological effects of a saponin-rich fraction (SFG) obtained from crude methanolic extract of Ficus platyphylla stem bark were studied on spontaneous motor activity (SMA); pentobarbitalinduced sleep; motor coordination; amphetamine-induced hyperactivity and stereotyped behaviour; catalepsy; forced swim and tail suspension tests in rodents. SFG reduced SMA dose dependently; suggesting that it may contain psychoactive principles with sedative effects. The fraction shortened the onset and prolonged the duration of pentobarbital-induced sleep; which confirmed its sedative properties. The fraction diminished immobility time in forced swim and tail suspension tests; which is indicative of antidepressant properties. It attenuated amphetamine-induced hyperactivity and stereotyped behaviour; induced catalepsy and exacerbated haloperidol-induced catalepsy in rodents; but had no effect on motor coordination in the treadmill experiment at the doses tested. These effects were similar to those of classical neuroleptics and antidepressants. Our study provides scientific evidence of psychopharmacological effects of the saponin fraction of Ficus platyphylla stem bark and therefore supports further development of its psychoactive components as antipsychotics and antidepressants


Assuntos
Depressão , Ficus , Psicofarmacologia , Saponinas , Comportamento Estereotipado
2.
Indian J Exp Biol ; 2004 Aug; 42(8): 787-91
Artigo em Inglês | IMSEAR | ID: sea-61484

RESUMO

Effect of the aqueous leaf extract of I. gabonensis on the gastrointestinal tract was investigated on isolated rabbit jejunum, guinea pig ileum, gastrointestinal motility, castor oil-induced diarrhoea in mice and castor oil-induced fluid accumulation in rats. The results showed that the extract exhibited a concentration-dependent relaxation of spontaneous pendular movement of isolated rabbit jejunum and guinea pig ileum, and attenuated both acetylcholine-induced contraction of rabbit jejunum and histamine-induced contraction of guinea pig ileum. The extract (100, 200 and 400 mg/kg) also caused a significant dose-dependent decrease of gastrointestinal motility in mice (40.12, 39.45 and 37.45%), intestinal fluid accumulation in rats (71.43, 81.63 and 83.27%), and remarkably protected mice against castor oil-induced diarrhoea [58.33, 75 and 91.67% (Di Carlo score)] respectively. Preliminary phytochemical screening of the aqueous leaf extract of I. gabonensis revealed the presence of saponins, tannins, phenols and phlobatanins.


Assuntos
Animais , Antidiarreicos/farmacologia , Celulose/farmacologia , Diarreia/tratamento farmacológico , Feminino , Motilidade Gastrointestinal/efeitos dos fármacos , Trato Gastrointestinal/efeitos dos fármacos , Cobaias , Masculino , Camundongos , Fitoterapia , Extratos Vegetais/farmacologia , Coelhos , Ratos , Ratos Wistar , Simaroubaceae
3.
Indian J Exp Biol ; 2002 May; 40(5): 571-4
Artigo em Inglês | IMSEAR | ID: sea-61724

RESUMO

Effects of the aqueous extract of T. sessilifolius on the gastrointestinal muscle were investigated on smooth muscle preparations isolated from rabbit jejunum, guinea pig ileum and on gastrointestinal transit in mice. Elemental analysis of the extract was also carried out. The aqueous extract of T. sessilifolius evoked a concentration dependent contraction of the rabbit jejunum and guinea pig ileum. The contractions evoked by the extract were not attenuated either by atropine or mepyramine, but they were completely blocked by verapamil. The elemental analysis revealed the presence of Mg, Zn, Fe, Cu, and very high concentration of Ca. The intraperitoneal LD50 in mice was found to be 1500 mg/kg. The aqueous extract of T. sessilifoliius possesses active components that may be mediating the observed biological activity through calcium mobilization.


Assuntos
Animais , Feminino , Trânsito Gastrointestinal/efeitos dos fármacos , Cobaias , Íleo/efeitos dos fármacos , Jejuno/efeitos dos fármacos , Dose Letal Mediana , Masculino , Camundongos , Erva-de-Passarinho/química , Músculo Liso/efeitos dos fármacos , Extratos Vegetais/farmacologia , Folhas de Planta/química , Coelhos
4.
Indian J Exp Biol ; 2001 Jan; 39(1): 63-7
Artigo em Inglês | IMSEAR | ID: sea-57938

RESUMO

Methanolic extract of Ficus platyphylla was tested on isolated rabbit jejunum, rat duodenum and gastrointestinal motility in mice. The extract showed a biphasic effect on isolated smooth muscle. Lower concentration of extract caused contraction, while higher concentrations produced relaxation. The contractile phase was attenuated by atropine, while relaxant phase attenuated histamine induced contraction of guinea pig ileum. The extract also exhibited a dose-dependent inhibition of gastrointestinal motility. Acute toxicity test in mice established LD50 value (i.p.) of the extract to be 2000 mg/kg. Preliminary phytochemical screening of the extract gave positive test for flavonoids, tannins and saponins.


Assuntos
Animais , Sistema Digestório/efeitos dos fármacos , Relação Dose-Resposta a Droga , Feminino , Trânsito Gastrointestinal/efeitos dos fármacos , Cobaias , Dose Letal Mediana , Masculino , Camundongos , Extratos Vegetais/farmacologia , Coelhos , Ratos , Ratos Wistar , Rosales/química
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA