RESUMO
Background : The common side effects of epidural morphine are prurits discomfort.Objective : To test the hypothesis that nalbuphine can prevent epidural morphine-induced pruritus and nausea vomiting.Design : Randomized controlled trial.Setting : Srinagarind hospital, Khon kaen university.Subjects : Sixty – four caesarean patients (ASA 1-2) were randomly assingned into 2 groups.Intervention : Epidural anesthesia with 2% lidocaine with adrenaline 1:200,000 18-20 ml. plus morphine 5 mg. was performed in every patient. After delivery of the babies patients in group 1 (n=32) received NSS 1 ml. and patients in group 2 (n=32) received nalbuphine 10 mg. intramuscularly.Measurements : Side effects of epidural morphine were observed for a 24 hour period. Results : The incidence of pruritus and nausea – vomiting were not different significantly between the two groups. No respiratory depression occurred.Conclusion : We concluded that nalbuphine 10 mg. given by intramuscular injection could not prevent epidural morphine-induced pruritus and nausea-vomiting.Key words : Epidural morphine, Side effects, Prevention, Nalbuphine.