RESUMO
Effect of chronic treatment with hydralazine (40 mg/kg/day) on isolated heart, anococcygeus muscle and myometrial preparations from rats has been studied. The treatment for 6 weeks caused a significant increase in isoprenaline induced positive inotropic response in rat heart. However, isoprenaline induced positive chronotropic effects were not altered significantly by chronic hydralazine treatment. Chronic hydralazine treatment also failed to alter noradrenaline induced contractile effects on rat anococcygeus muscle. However, on myometrial preparations from hydralazine treated rats showed an increase in adrenaline induced relaxations. The results of the present study can be explained on the basis of the effect of hydralazine on adenylate cyclase-cyclic adenosine monophosphate (cAMP).
Assuntos
Animais , Feminino , Hidralazina/farmacologia , Masculino , Ratos , Ratos Wistar , Fatores de TempoRESUMO
The effect of nifedipine, a calcium antagonist on fasting blood glucose level, glucose tolerance, glucose-induced insulin and glucagon secretion was studied in healthy nondiabetic volunteers. Nifedipine 10mg twice daily for four weeks did not affect fasting blood glucose level, glucose tolerance, glucose-induced insulin and glucagon secretion.
Assuntos
Adulto , Glicemia , Humanos , Masculino , Nifedipino/farmacologiaRESUMO
Carbamazepine (CA) and sodium valproate (SV) were studied for their actions of central nervous system and neuromuscular junction. CA and SV given ip neither possessed analgesic nor hypothermic activity in rats, nor did they alter the pentobarbitone sleeping time in mice. The drug had no effect on the frog rectus muscle nor did they alter its responses to acetylcholine. Both CA and SV produced a dose related decrease in indirectly evoked contractions of rat diaphragm and cat gastrocnemius muscle without much altering the directly evoked responses. This effect may be due to their local anaesthetic property, which was observed in infiltration test in guinea pigs.
Assuntos
Animais , Anuros , Temperatura Corporal/efeitos dos fármacos , Carbamazepina/farmacologia , Gatos , Sistema Nervoso Central/efeitos dos fármacos , Potenciais Evocados/efeitos dos fármacos , Camundongos , Contração Muscular/efeitos dos fármacos , Junção Neuromuscular/efeitos dos fármacos , Coelhos , Ratos , Sono/efeitos dos fármacos , Fatores de Tempo , Ácido Valproico/farmacologiaAssuntos
Acetilcolina/farmacologia , Animais , Atropina/farmacologia , Cálcio/farmacologia , Interações Medicamentosas , Epinefrina/farmacologia , Histamina/farmacologia , Contração Miocárdica/efeitos dos fármacos , Potássio/farmacologia , Coelhos , Ranidae , Especificidade da Espécie , Ácido Valproico/farmacologiaRESUMO
Six basic amides were screened for local anaesthetic activity and compared with procaine and lignocaine. Amongst the basic amides screened, piperidino-N-(alpha-4-ethoxy phenyl- beta-phenyl) ethyl and Diethylamino-N (alpha-4-ethoxy- beta-phenyl) ethyl acetamide were found to be more effective as compared to lignocaine. They were found to be non-irritant, and non-toxic even in high doses.