RESUMO
Antiinflammatory, analgesic and antipyretic activities of glycosidal fraction isolated from M. chisia were compared in battery of animal tests with known nonsteroidal antiinflammatory drugs (NSAIDs). The pharmacological activities compared favourably with NSAIDs whereas remarkable lack of toxicity was an added advantage.
Assuntos
Animais , Anti-Inflamatórios não Esteroides/farmacologia , Artrite/tratamento farmacológico , Edema/tratamento farmacológico , Glicosídeos/farmacologia , Granuloma/tratamento farmacológico , Camundongos , Camundongos Endogâmicos BALB C , Extratos Vegetais/farmacologia , Ratos , Ratos EndogâmicosAssuntos
Abortivos , Alcaloides , Animais , Feminino , Cobaias , Plantas Medicinais , Gravidez , Quinazolinas , RatosAssuntos
Animais , Cães , Avaliação Pré-Clínica de Medicamentos , Feminino , Cobaias , Índia , Masculino , Extratos Vegetais/farmacologia , Plantas Medicinais , Coelhos , RatosAssuntos
Alcaloides/farmacologia , Animais , Feminino , Cobaias , Tono Muscular/efeitos dos fármacos , Gravidez , Coelhos , Ratos , Estimulação Química , Útero/efeitos dos fármacosRESUMO
Embelin, obtained from Embolin ribes was condensed with different primary amines. Depending on the conditions of reaction, disalts or diimines were formed. Ten such disalts and fourteen diimines were developed. Embelin and all its disalts showed analgesic activity whereas all the diimines derivatives were inactive. The disalt, 2:5 disobutyl amine embelin showed maximum action. Analgesic effect was noticed only after intraperitoneal administration but not after subcutaneous, intramuscular or oral administration. The compounds cause some local irritation. The possibility of peritoneal irritation rendering the animals unresponsive to experimental pain seems to deserve consideration. However, analgesic effect could be seen in dogs and cats after intravenous injection. Embelin and its disalt, 2:5 isobutyl amine embelin also exhibited antipyretic and antiinflammatory activities.