use of 2,6-dichloro quinone chloride for the colorimetric determination of some antibiotics

A simple, sensitive and facile colorimetric method for quantitative determination of amoxicillin, cefadroxil and ceforperazone is developed. The method is based on the formation of blue colored chromogen upon the reaction of the investigated drugs with 2,6-dichloroquinone chlorimide in alkaline medium. The optimal experimental parameters for the color production are selected. Obedience the Beer's law permitted the successful application of the developed method for the assay of investigated drugs in their pharmaceutical dosage forms. The results obtained are compared with the reported method

Utility of tetrazolium blue for the spectrophotometric determination of azlocillin and ceftriaxone

A simple and sensitive spectrophotometric method was described for the assay of azlocillin and ceftriaxone in injections. The method was based on the reduction of tetrazolium blue in alkaline medium by the two drugs, giving a highly colored formazan measurable at 524 nm. The optimization of the different experimental conditions was described. The method proved to be accurate and reproducible as indicated by a relative st and ard deviation of less than 2%

Spectrophotometric determination of mequitazine and thiopentone sodium in dosage forms

A simple and sensitive spectrophotometric method was described for the determination of mequitazine and thiopentone sodium. The method was based on the formation of ferroin upon reaction of these drugs with iron [III]-o-phenanthroline reagent. The colored product was quantitated spectrophotometrically at 510 nm. Beer's law was obeyed over concentrations ranging from 0.2 to 0.8 mg% and 2 to 6 mg% for mequitazine and thiopentone sodium, respectively. The proposed method has been applied successfully to the determination of the investigated drugs in dosage forms

Spectrophotometric determination of mequitazine

Two simple and sensitive spectrophotometric assay procedures were described for the determination of mequitazine. The first was based on the reaction of the drug with aconitic anhydride to give a red colored product measurable at 547 nm. The second depended on the oxidation of the drug with sodium nitroprusside in the presence of concentrated HCl to give a violet color with a maximum absorbance at 569 nm. Optimization of the experimental conditions was described. The proposed methods were applied to the determination of mequitazine in tablet form

Spectrophotometric determination of amoxicillin and cefadroxil using 3-methyl-2bencothiazolone hydrazone hydrochloride

A spectrophotometric method was described for the determination of amoxycillin and cefadroxil. The method was based on the reaction of these drugs with 3-methyl-2-benzothiazolone hydrazone hydrochloride [MBTH] in the presence of cerric ammonium sulfate. The colored products were estimated spectrophotometrically at 530 nm and 511 nm for amoxycillin and cefadroxil, respectively. Beer's Law was valid over the concentration range 10-50 mug ml -1. The method was applied successfully to the analysis of dosage forms. Relative st and ard deviations for the assay of both drugs in commercial preparations were less than 1%

Volumetric determination of piroxicam in presence of degradation product

An indirect volumetric method for the determination of piroxicam is developed. It depends on the reaction of piroxicam with a measured excess of ammonium-cerric-sulfate in sulfuric acid medium. The excess cerric is back titrated with st and ard ammonium ferrous sulfate using ferroin as indicator. The molar ratio of the reactants was determined to be one drug to four ammonium-cerric-sulfate. The method was successfully applied for the determination of piroxicam in pharmaceutical preparations. The presence of 2-aminopyridine, the degradation drug product, did not interfere with the accurate determination of piroxicam. The validity of the method was checked using the st and ard addition technique