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J Environ Biol ; 2002 Jul; 23(3): 231-7
Artigo em Inglês | IMSEAR | ID: sea-113573

RESUMO

Non-lethal dose of 70% ethanol extract of the Nerium oleander dry leaves (1000 mg/kg body weight) was subcutaneously injected into male and female mice once a week for 9 weeks (total 10 doses). One day after the last injection, final body weight gain (relative percentage to the initial body weight) had a tendency, in both males and females, towards depression suggesting a metabolic insult at other sites than those involved in myocardial function. Multiple exposure of the mice to the specified dose failed to express a significant influence on blood parameters (WBC, RBC, Hb, HCT, PLT) as well as myocardium. On the other hand, a lethal dose (4000 mg/kg body weight) was capable of inducing progressive changes in myocardial electrical activity ending up in cardiac arrest. The electrocardiogram abnormalities could be brought about by the expected Na+, K(+)-ATPase inhibition by the cardiac glycosides (cardenolides) content of the lethal dose.


Assuntos
Animais , Peso Corporal , Relação Dose-Resposta a Droga , Eletrocardiografia , Feminino , Coração/fisiologia , Parada Cardíaca/induzido quimicamente , Masculino , Camundongos , Nerium/química , Extratos Vegetais/toxicidade , Folhas de Planta/química
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