Clinical efficacy of unani herbal formulation garlina against primary hyperlipidemia

Primary hyperlipidemia and atherosclerosis are correlated to each other and these are major cibdutuuibs of coronary artery diseases. The objective of the study was to evaluate the efficacy of polyherbal Unani medicine [Garlina] a well-known herbal formulation to be used for Primary hyperlipidemia. This was an open, randomized, prospective, multicenter study on human subjects of 6 months duration. After the laboratory investigations for fasting plasma lipids of the suspected subjects, 25 subjects were identified, randomized and received the drug. The subjects were diagnosed and classified according to the international recommended levels of plasma lipids [PL] as total cholesterol levels were borderline high [200-239 mg/dL], triglycerides [TGs] were high [200-499 mg/dL], high density lipoprotein [HDL] were desirable but not optimal [41-59 mg/dL] while low density lipoproteins [LDL] were borderline high [130-159 mg/dL]. After 8 weeks administration of Garlina tablets 500 mg twice-a-day, the total cholesterol levels were reduced to 166.48+/- 35.59 mg/dL from 224.04+/-9.16 mg/dL, triglyceride levels were also reduced to 144.28+/- 37.11 mg/dL from 217.28+/-73.54 mg/dL at the base line, low density lipoprotein levels were reduced to S7.52+/-40.17 mg/dL from 133.96+/- 54.00 mg/dL while high density lipoprotein level was increased to 56.20±8.66 mg/dL from 48.28+/-10.57 mg/dL. The findings from this study demonstrated that there was significant difference [p<0.05] before and after treatment with Garlina [500 rqg] as mean lipid profiles of test group administered 1 tablet b.d. after meals. This is clearly evident that Garlina possesses a significant hypolipidemic therapeutic value for the treatment of primary hyperlipidemia

Alternative treatment in Hepatitis B by using polyherbal formulation

The hepatitis B is most prevalent diseases [along with morbidities] in Asian countries. This research study has been conducted to provide an alternative treatment which is safe, effective and cost-effective to comprehend relations of disease, symptoms, patients response and the clinical response via better management of hepatitis B. The goal of this research is to evaluate efficacy and safety of herbal medicine as compared to allopathic medicine in patients suffering from hepatitis B. This was a single blind, randomized controlled clinical trial conducted at Shifa-ul-Mulk Memorial Hospital Hamdard University, Karachi and Dar ul Shifa Unani Dawakhana Karachi, Pakistan. The patients of both genders ranging from 25 to 50 years with symptoms and diagnosed for hepatitis B that fulfilled the criteria for membership, and consented for participation were registered. Ethical committee clearance and permission was obtained from the concerned committee at Faculty of Eastern Medicine, Hamdard University, Karachi, Pakistan. No significant difference was identified after treatment and it was found that the efficacy of Alpha [Control drug] is same as Safoof akseer e jigar [Test drug]. The data offered support to the null hypothesis and therefore research hypothesis was rejected. According to the statistical analysis by chi square, hepatitis B was recorded as negative in 26 patients [57.77%] out of 45 patients by the use of Interferon Alpha [control therapy] and in 27 patients [64.28%] out of 42 patients by the use of Safoof akseer e jigar [test drug]. Comparison of the data recorded of the patients was determined as both drugs showed significant improvement and p value>0.05. The efficacy response is equal in both drugs while test drug showed more safety response. It is concluded that Safoof akseer e jigar possesses as effective a therapeutic value in treating hepatitis B as allopathic medicine

Efficacy of Gingocap as compared to pyridoxine in the treatment of nausea and vomiting during pregnancy

Nausea and vomiting is the common problem disturbing almost 80% of the females in initial three months of conception and later sometime throughout pregnancy. To find out the efficacy and safety of herbal coded test drug Gingocap in comparison with the control drug Pyridoxine, a randomized clinical case control study was conducted at the OPD of Yusra Medical Centre, Karachi and Amir Habib Medical Center and Maternity Home, Karachi. After administration of test and control drug the frequency of nausea and vomiting was noted after every 2 weeks on 2nd, 4th, 6th and 8th weeks during 60 days of the course of study. The percentage of reduction of nausea and vomiting symptoms from the baseline in cases treated with test Gingocap compared to control drug Pyridoxine was recorded. Overall 35 and 30 patients were administered Gingocap and Pyridoxine between 6-16 weeks conception respectively. The data analyzed through T-test using SPSS version 18.0. It was concluded that Gingocap has the potential to relieve the symptoms of nausea and vomiting and exhibited no side effects and this drug was acceptable by maximum number of the patients

Plantago ovata: clinical study of overuse

The objective of the study was to undertake evidence-base study to evaluate clinical manifestation of the overestimated use of herbal drug Plantago ovata and to compare it with placebo for the efficacy and adverse effects. The patients of both genders were included. Blood urea, creatinine, ALT, Serum B12, CP, ESR and liver function tests were performed. The data was statistically analyzed in both groups for differential symptomatology. In anorexia test verses control results showed that Plantago ovata husk and placebo showed the affected ratio as 81 percent and 50 percent, correspondingly. Whereas in clinical performance of heart burning, pain in epigastrium, low libido, body pain, dyspepsia, fever, burning sensation in palm and sole in test drug showed affected response as adverse effect 90%, 88% and as control drug, 36%, 29%, 22%, 25%, 38%, 30%, 33%, 57%, respectively. The results were highly marked in test drug i.e. in comparison with placebo. This is clearly evident from data analysis that effect observed in test arm is far more superior hence null hypothesis was rejected clearly. Similarly serological and biochemical reports study i.e. [ALT, Vit. B1 and Vit A] revealed that there is no hepatotoxic and neurotoxic effect found in both the drugs

Alternative treatment for iron deficiency anemia: Irocbin versus sherbat Faulad Sultan

The widespread reason of anemia is Iron deficiency in Pakistan and even worldwide. A clinical trial was undertaken to assess the efficacy of Irocbin formulation for the treatment of iron deficiency anemia as compared to Sherbat Faulad. The curative evaluations of these medicines were recorded in clinically and biochemically identified cases of iron deficiency anemia. The therapeutic evaluation of the different drugs both test and control drug were conducted on the bases of improvement in the subjective signs and symptoms, clinical observations and biochemical investigations at periodic intervals during the course of therapy. This data was collected in the period November 2010 to November 2012 and completed the clinical trials. According to the statistical analysis comparison of data recorded by patients concerning to different variables, showed significant results between test and control groups [p<0.05]. By applying ANOVA test, the p values for multiple comparisons of the levels of improvement of Hemoglobin after treatment exhibited significant difference as compared Sherbat Faulad and Irocbin. The control drug Sherbat Faulad with only iron component improves Hemoglobin level and the sign and symptoms but associated with side adverse effects

Ways to manage hepatitis C without cirrhosis: treatment by comparison of coded eastern medicine hepcinal with interferon alpha 2b and ribavirin

Hepatitis C virus [HCV] infection is a serious and significant global health problem in the Pakistan and elsewhere. In majority of cases HCV infection remains asymptomatic but in advance cases it may progress to fibrosis of liver, shrinkage of liver cells or failure of liver. The hepatitis C may progress to cause liver cirrhosis that mostly develop in 20% of the affected patients in 20 years with an increased risk in male, alcoholic drink, immune-compromised and who acquire HCV infection after the age of 40 years. This was an open-label prospective study conducted on 66 clinically and immunologically diagnosed cases of HCV infection. In Hepcinal treated group, there were significant improvement in HCV associated symptoms compared to control group [p<0.05]. While Interferon therapy resulted in significant improvement in serological response [55.88%] compared to Hepcinal treated patients [46.88%]. It was concluded that Hepcinal has shown better clinical response but no significant serological response [p=0.3244] and it might be an alternative therapy to treat hepatitis C infection and to prevent its progression into chronic ailment

Comparative clinical study on the efficacy of biocor plus compared with simvastatin for the management of hypercholesterolemia

Hypercholestriolemia is major risk factor that enhances the incidence of cardiovascular disease and coronary artery disease. The present study was conducted to normalize the lipid profile in the blood by using Biocor Plus for hypercholesterolemia compared with Simvastatin. It was prospective randomized case control study conducted on 70 diagnosed patients of hypercholesterolemia at Sohail Memorial Hospital, Karachi and Amir Habib Medical Center and Maternity Home, Karachi. Patients of both genders [30-70 years] with clinical diagnosis of Hypercholesterolemia. Sample sizes for this study included total of 70 subjects. There was statistically significant difference when comparing the effectiveness of test drug, Biocor Plus to control drug, Simvastatin for the treatment of primary hypercholesterolemia. This is clearly evident that the herbal coded test drug, Biocor Plus possesses a therapeutic value for the treatment of primary hypercholesterolemia. There were no untoward or significant side effects associated with the use of Biocor Plus that proved its good acceptability by the patients. Moreover there was subjective feeling of wellbeing regarding breathlessness and chest tightness or pressure in the patients taking Biocor Plus. This makes an interesting point to focus on this effective alternative drug for primary hypercholesterolemia

Clinical assessment of coded Unani formulation D-worm and mebandazole for the treatment of hook worm, roundworm and whip worm

A case control, multicenter, prospective randomized two arm parallel group clinical trials was conducted on 190 patients. The main objective of this study is to provide comparative efficacy results of both trialed medicines. The comparison was done in between herbal medicine D-Worm and Mebandazole allopathic drug for the treatment of helminthiasis. All the rules of GCP [Good Clinical Practices] were followed including clinical history, clinical presentation, examination findings and stool tests. Stool D/R and Parasite antigen tests were performed before and after treatment. The comparison of symptoms were also done including the improvement in abdominal pain, worms in stool, anal itching, nausea and vomiting, loss of appetite, and fatigue etc. The data on clinical proforma was gathered and subjected to statistical analysis. Parasite specific antigen test and stool D/R is considered as gold standard test for the diagnosis and confirmation of helminthes infection. Different parameter i.e. age, sex, and other clinical sign and symptoms were studied and compared between two treatment groups [Control and Test groups] at baseline and end of therapeutic application. Consent of patient was taken at first before the start of examination. Majority of the patients [90%] included in this study group get cured after herbal treatment. The statistical analysis used for the assessment of the effect of the treatment also showed significant improvement after treatment

Clinical efficacy of polyherbal formulation Eezpain spray for muscular pain relief

The topical herbal formulation Eezpain spray consisting of natural ingredients that have been clinically proved for its analgesic and anti-inflammatory activity. The designed formulation on application knee and wrist joints, back of neck and shoulder, forearms and lower back exhibited significant efficacy. A total of 20 subjects both male and female applied Eezpain spray consisting of Gaultheria oil, Eucalyptus oil, Turpentine oil, Clove Oil, Menthol and Camphor. All the active materials are cited that these have analgesic activity in myalgia and neuralgia. The study design was prospective and opens as pilot study followed the inclusion and exclusion criteria. All the sign and symptoms were noted at baseline and at the end of 14 days treatment performance was evaluated. The statistical analysis was done by using Microsoft Excel2007 and SPSS version 18.0. It is concluded that Eezpain spray has shown efficacy in mild to moderate cases on applying locally to the affected parts to relieve pain from different ailments

Comparative clinical efficacy and safety of coded herbal medicine dermovix in the management of patients with atopic dermatitis versus allopathic medicine

Atopic dermatitis [AD] is defined as a chronic, highly pruritic inflammatory condition of skin. It is estimated that this disease may lead significant morbidity and also adversely affects the quality of life. Atopic dermatitis responds well to home treatment. Proper skin care reduces the need for medicines. Topical creams and oral antihistamines can be used to suppress the symptoms. The clinical trial was conducted on 60 patients in which 30 are control and 30 are test by taking written consent from them. Dermovix significantly improved skin symptoms associated with AD. This Dermovix ointment was safe and well tolerated in specified age group patients. Overall results of individual group were analyzed by using Paired sample t-test and level of significance of all the symptoms was calculated. Both the drugs showed similar efficacy and the calculated p value was p<0.05. Except in case of dry skin the test drug had shown not significant p value i.e. 0.407. When we compare all these and their effects and patients' complaints then Test group have shown better results because of no side effects

Clinical evaluation of herbal coded formulation cran-off to urixin in the treatment of urinary tract infection

Urinary Tract Infections are the largest group of infections after the respiratory tract infections. In 85% of the cases the causative organism is E. Coli. A clinical trial was conducted to evaluate the efficacy of coded herbal formulation [Cran off] [Test drug] for the treatment of Urinary tract infection comparing with Urixin [Control]. One hundred and thirty patients suffering from Urinary tract infection from both groups [Males: 45, mean age: 34+/-14 and females: 85, mean age: 33+/-13 year, range: 15-55] were enrolled in the trial and divided in to two groups according to treatment regimens. Cran off [Test drug] 500mg two capsules and Urixin [Pipemidic Acid Trihydrate JP15] [Control] 400mg capsules twice daily were prescribed for 2-3 weeks. Urinary tract infection was improved in 23 [35.38%] patients out of 65 patients by the use of Cran off [Test drug], and in 15 [23.07%] patients out of 65 by the use of Urixin [Control drug]. Furthermore, there was a significant improvement in Urinary tract infection associated clinical features as compared to Urixin. It is concluded that Cran off possesses a therapeutic value for the improvement of urinary tract infection and its associated symptoms as compared to Urixin

Comparative clinical evaluation on herbal formulation Pepsil, Safoof-e-Katira and Omeprazole in gastro esophageal reflux disease

This study was conducted to evaluate the role of Unani herbal drugs Pepsil and Safoof-e-katira on the gastro esophageal reflux disease [GERD]. This was multicentre r and omized case control study conducted at Matab Hakeem Muhammad Noor-ud-din, Burewala; Aziz Muhammad din Medical and Surgical Centre, BurewalaandShifa-ul-mulk Memorial Hospital, Hamdard University Karachi. The patients were selected according to inclusion and exclusion criteria. In test group-1 the male female ratio was 40%, 60%; test group-2 was 42%, 58% and in control group was 44%, 56% respectively. The observed symptoms in the study were increased appetite [TG-1-95%, TG-2-95% and CG-89%], difficulty in swallowing [TG-1-93%, TG-2-96% and TC-94%], belching/burping [TG-1-97%, TG-2-97% and CG-95%], vomiting [TG-1-90%, TG-2-96% and CG-89%], heart burn [TG-1-100%, TG-2-100% and CG-98%], palpitation [TG-1-100%, TG-2-100% and CG-97%], epigastric pain [TG-1-97%, TG-2-97% and CG-90%], abdominal cramps [TG-1-97%, TG-2-98% and CG-95%], tenesmus [TG-1-100%, TG-2-100% and CG-97%], flatulence [TG-1-100%, TG-2-75% and CG-95%], wakeup during sleep [TG-1-94%, TG-2-87% and CG-94%]. The p-value of the results of the symptoms was 0.000 except flatulence where the value was 0.001. The statistical results of the study prescribed that all the drugs studied [Pepsil, Safoof-e-katiraandOmeprazole] are highly significant. The herbal coded drug Pepsil showed no side effects and unani herbal drug safoof-e-katira showed minimum result of 75% in the patients while Omeprazole resulted with some side effects. In the result it can be concluded that the herbal coded drug Pepsil is a potent herbal drug for gastro esophageal reflux disease.

Clinical efficacy of herbal coded formulation Ocucure for the improvement of presbyopia: a randomized comparative clinical trial

A progressively diminishing capacity of eye to visualize for close proximity increasing by age is known as presbyopia which is usually resulted due to loss of elasticity of crystalline lens. A clinical trial was conducted to evaluate the efficacy of coded herbal formulation "ocucure" [Test drug] for the treatment of presbyopia comparing with leutivit [Placebo]. One hundred and eleven patients suffering from presbyopia from both groups [Males: 63, mean age: 34 +/- 14 and females: 48, mean age: 33 +/- 13 year, range: 20-60] were enrolled in the trial and divided in to two groups according to treatment regimens. Ocucure [Test drug] 500mg two tablets and leutivit [Placebo] 250mg tablets twice daily were prescribed for 6-8 weeks. Presbyopia was improved in 17 patients [28.81%] out of 59 patients by the use of ocucure [Test drug], and in 6 patients [11.53%] out of 52 by the use of leutivit [Control drug]. Furthermore, there was a significant improvement in presbyopic associated clinical features as compared to leutivit. It is concluded that ocucure possesses a therapeutic value for the improvement of presbyopia and its associated symptoms as compared to leutivit

Disease pattern at the paediatric opd of shifa ul-mulk memorial hospital, hamdard university, madinat Al-Hikmah, Karachi

To study disease prevalence and determine disease pattern in the 28 villages around Madinat al-Hikmah, a retrospective study has been carried out at the Department of Clinical and Pre-Clinical Sciences, Shifa ul-Mulk, Memorial Hospital, Hamdard University, Madinat al-Hikmah, Karachi, Pakistan. Three groups have been made on yearly basis from January 2001-June 2003. Review has also been conducted according to age, sex and disease pattern. It was found that respiratory and diarrhoeal diseases top the list. Male to female ratio was nearly 2:1 and highest numbers of patients are under the age of 5-yrs. It was concluded that morbidity and mortality is highest in under 5-years age group, hence special attention is required to deal with patients of this age group

Community based epidemiological/statistical studies of male patients/diseases in out-patient-department at Shifa-ul-Mulk memorial hospital for Eastern Medicine

Shifa-Ul-Mulk Memorial Hospital for Eastern Medicine is the first and only Hospital in Pakistan, providing health care facilities through Unani/herbal System of Medicine. It is a 50-beded Hospital providing free health care. It has well equipped Wards, Laboratory, Operation Theater, Labour room, etc. The Hospital was founded in 2000 and since, it is the only Health Care Center of <28 villages near the city of education, Bait-Ul-Hikmah. Statistical data based on number of patients, diseases, age groups, etc has long been needed in order to promote and elevate the health care facilities to the patients of the rural areas around the Bait-Ul-Hikmah. The objective of our study is to determine the prevalence of male diseases specially those, not responded to therapies of modern medicine. Also, we have an eye on the diseases which are occurring more frequently, so that we are able to target the etiology and better management of these diseases. 35,216 male patients were seen at the OPD. 6,919 in the Year 2000, 9,144 in 2001, 9,693 in 2022 and 9460 in 2003. Number of patient's increases from 2000 to 2002 and decreases in 2003. Disease of GIT [34.47%] has the highest prevalence while Respiratory disease [22.89%] being the second. Age group of 18-45 years has got the largest numbers and most of the patients were married. Respiratory, skin and infectious diseases are more common in children

Comparative study of [Leuko-off coded herbal formulation] vs. metronidazole [allopathic medicine] for bacterial vaginosis and trichomonal infections

Vulvovaginitis is one of the common problems that women's has to face in their lifetime. The women are more susceptible of these infections and that they are increasingly vulnerable to infection from the anatomic as well as hormonal point of view. Bacterial vaginosis and trichomoniasis are common examples that occur after the change in the vaginal ecosystem1o Single-line therapy is often inadequate and recurrence is common. So there is a need of treatment, which should be safe and effective. A random controlled clinical trial was conducted to compare the anti-bacterial and anti-trichomonal activity and safety of coded herbal medicinal treatment Leuko-off with Metronidazole. All subjects were clinically studied and completed the assigned therapy during the period May 2001 to June 2004. The clinical evaluation was carried out on 45 patients of ages between 14-48 years with the complaint of vaginal discharge at Department of Gynecology and Obstetrics in Shifa-ul-Mulk Memorial Hospital for Eastern Medicine at Hamdard University, Hamdard Matab Aram Bagh in Karachi and Civil Hospital, Karachi

Objective of Study: To investigate the efficacy and safety of coded herbal medicine "Leuko-ofr' for the treatment of bacterial vaginosis and trichomonas infections and provide a comparison between herbal medicine and current allopathic treatment Metronidazole" for bacterial vaginosis and trichomonal infections

Conclusion: Consequently the generated data offered support to the null hypothesis [when P>0.05] hence the null hypothesis was rejected on the basis of statistical findings with regard to efficacy, safety, drug compliance and cost effectiveness [P<0.05]