Ameliorative effects of whole soybean and oat grains in adrenaline-induced dyslipidemia

This investigation was planned to clarify the anti-dyslipidemic therapeutic effects of a food product containing soybean and/or oat grains in experimental dyslipidemia. A total of 35 adult male albino rats were divided into five groups, normal control, dyslipidemic control, dyslipidemic experimental group fed with soybean product, dyslipidemic experimental group fed with oat grains product and dyslipidemic experimental group fed with the two products in combination Dyslipidemia was induced to rats by injection intraperitonealy with adrenaline. After 30 days of treatment with the plant products, data analysis revealed that there were highly significant increases in the serum concentrations of total cholesterol, low-density lipoprotein [LDL] cholesterol and triglycerides in the dyslipidemic group compared with the normal group. On the other hand, High-density lipoprotein [HDL] cholesterol concentration was highly significantly decreased. Administration of soybean product exhibited a significant decreasing effect on serum total cholesterol and LDL cholesterol concentrations, a significant increasing effect on serum HDL cholesterol level and an obvious improvement in serum triglycerides level which was not statistically significant. Treatment with oat grains containing product showed highly significant decreasing effect on the serum level of total cholesterol, non- significant improvement in LDL cholesterol concentration, a significant increasing effect on serum HDL cholesterol level and non- significant decreasing effect on the level of triglycerides. Administration of the two products in combination exhibited a significant decreasing action on total cholesterol concentration, a highly significant modulation in the impaired LDL cholesterol level, a highly significant increasing effect on serum I-1DL cholesterol level and a significant reduction in triglycerides level as compared with the dyslipidemic control group. The current data demonstrated that regular consumption of whole soybean and oat grains products exhibited marked anti-dyslipidemic modulatory actions on the impaire4 serum lipid and lipoprotein profiles in adrenaline-induced experimental dyslipidemia. Generally, the effect of the two products in combination was more effective than the effect of cacti of them alone

Comparison between morning and evening single dose administration of fluvastatin in hypercholesterolemic male albino rats

The concepts of chronobiology, circadian rhythm, chronopharmaology, homeostasis and chronotherapy are taken into account to approach the optimal drug therapy, in which the timing of drug administration plays an important role. Dyslipidemia is a primary, major risk factor and may be a prerequiste for coronary artery disease [CAD], occurring before other major risk factors come into play. Lipid-altering drug treatment, targeted to patients at high risk for cardiovascular disease [CVD], has been shown [in clinical trials] to reduce the incidence of first and recurrent CVI] events. The statins represent drugs of first choice for treatment of hypercholesterolemia. The aim of the present study is to determine the proper time of administration of the drug to achieve the best benefits for the hypercholesterolemic patients. The experiments were carried out on thirty two male albino rats that were divided into four equal groups; control normocholesterolemic, hypercholesterolemic non-treated, hypercholesterolemic treated in the morning with fluvastatin [8 mg/kg for 21 days] and hypercholesterolemic treated in the evening with fluvastatin [8 mg/kg for 2! days]. The present study demonstrated that administration of a single dose of fluvastatin [8 mg/kg/day for 21 days], whether given in the morning or in the evening for hvpercholesterolemic rats, significantly decreased serum total cholesterol levels in comparison with non-treated hypercholesterolemic animals. Also, fluvastatin treatment whether given in the morning or in the evening produced a significant increasing effect on high density lipoprotein serum level in comparison with the non-treated hypercholesterolemic animals. On the other hand, the level of low density lipoprotein in the evening treated hypercholesterolemic rats was siginficantly decreased, while, the morning treatment with fluvastatin showed an insignificant decreasing effect. Also, fluvastatin treatment, whether given in the morning or in the evening produced insignificant effect on serum triglycerides level in comparison with non-treated animals. Significant increase in the activity of glutathione peroxidase in serum was observed in the evening treated group in comparison with non-treated hypercholesterolemic animals, while, the morning treatment with fluvastatin showed insignificant increasing effect on glutathione peroxidase activity. Fluvastatin treatment whether given in the morning or in the evening showed nonsignificant decreasing effect on lipid peroxides content in serum in comparison with non-treated animals. It is concluded from the present data that therapeutic efficiency of fluvastatin is best obtained when the drug was administered in the evening rather than in the morning