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Objective:To analyze the multi-slice spiral CT (MSCT) scan signs and the expression of vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC) patients.Methods:A total of 51 patients with HCC admitted to our hospital from April 2015 to December 2018 were enrolled. The VEGF positive rate, microvessel density (MVD) level, HCC VEGF positive and negative MVD levels, and MSCT were compared between HCC and paracancerous tissues. The level of angiogenesis index was scanned and the association between MSCT scan signs and VEGF and MVD was analyzed.Results:The positive rate of VEGF and MVD in HCC tissues were higher than that in adjacent tissues ( P<0.05); MVD in patients with VEGF positive HCC was higher than that in patients with VEGF negative ( P<0.05); There was no significant difference in the positive rate of VEGF and MVD between patients with lesions >5 cm and ≤ 5 cm ( P>0.05). The VEGF positive rate and MVD in patients with pseudocapsule without / incomplete were higher than those in patients with intact capsule; the VEGF positive rate and MVD in patients with high risk invasion were higher than those in patients with low risk; the VEGF positive rate and MVD in arterial blood supply were higher than those in patients with dual supply and insufficient blood supply ( P<0.05); MSCT scan showed that false capsule without / incomplete, high risk of invasion, arterial blood supply and double supply were positively correlated with VEGF and MVD, while less blood supply was negatively correlated with VEGF and MVD ( P<0.05). Conclusions:MSCT scan can accurately evaluate the size of HCC lesions, the presence of false capsule, invasion and metastasis, enhancement type, etc. No/incomplete pseudocapsule, high-risk invasion, arterial blood supply and dual supply are positively correlated with VEGF and MVD, while less blood supply is negatively correlated with VEGF and MVD. This can pro-vide a new rapid, simple and non-invasive examination method for the evaluation of tumor neovascularization and diagnosis and prognosis for HCC.
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Objective@#To evaluate the clinical value of CT axial scan combined with multiplanar reconstruction(MPR) imaging in preoperative diagnosis of elderly patients with intestinal perforation.@*Methods@#From March 2017 to March 2019, 127 patients with suspected intestinal perforation in Dajiangdong Hospital were enrolled.The patients were examined by CT axial scan and MPR, 119 patients confirmed intestinal perforation by postoperative pathological diagnosis.According to the requirements of this study, one radiologist analyzed the CT axial scan image independently, and the other analyzed the CT axial scan combined with the MPR image also.The positive rate of CT axial scan analysis and the positive rate of CT axial scan combined with MPR image analysis were calculated.The pathological diagnosis was used as the gold standard, the positive rate of CT axial scan and the real perforation rate were compared, the positive rate of CT axial scan combined with MPR and the real perforation rate were compared, the positive rates of CT axial scan and CT axial scan combined with MPR were compared.The positive predictive values, negative predictive values, sensitivity, specificity and accuracy of CT axial scan and CT axial scan combined with MPR were calculated.@*Results@#Of 127 patients with suspected intestinal perforation, 86 cases were diagnosed and located by CT axial scan, with the positive rate 67.72%, 113 cases were diagnosed and located by CT axial scan and MPR, with the positive rate 88.98%.Finally, 119 cases were confirmed by pathological diagnosis, with the positive rate 93.70%.The difference between the positive rate of CT axial scan and the perforation rate of pathological diagnosis was statistically significant (67.72% vs.93.70%, χ2=27.537, P<0.001). There was no statistically significant difference between the positive rate of CT axial scan combined with MPR and the perforation rate of pathological diagnosis(88.98% vs.93.70%, χ2=1.792, P=0.181). The positive rate of CT axial scan was 67.72%, and the positive rate of CT axial scan combined with MPR was 88.98%, the difference was statistically significant (χ2=16.918, P<0.001). The positive predictive rate of CT axial scan was 95.35%, the negative predictive rate was 9.76%, the sensitivity was 68.91%, the specificity was 50.00%, and the accuracy was 67.72%.The positive predictive rate of CT axial scan combined with MPR was 99.12%, the negative predictive rate was 50.00%, the sensitivity was 94.12%, the specificity was 87.50%%, and the accuracy rate was 93.70%.@*Conclusion@#The combination of CT axial scan and MPR can improve the accuracy of preoperative diagnosis in elderly patients with intestinal perforation, which is worthy of clinical application.