Therapeutic effect of tracheal anastomosis versus interventional bronchoscopy in the treatment of airway stenosis / 南方医科大学学报

<p><b>OBJECTIVE</b>To compare the therapeutic effects of tracheal anastomosis and interventional bronchoscopy in the treatment of airway stenosis.</p><p><b>METHODS</b>From February, 1990 to February 2008, 53 patients with airway stenosis including 32 male and 21 female patients aged 2 to 80 years (mean 38 years) received end-to-end anastomosis or bronchoscopic stent-graft treatment in our hospital. End-to-end anastomosis of the narrow sleeves resected was performed in 26 cases, balloon dilatation in 14 cases, and stent implantation in 13 cases. The clinical and follow-up data of the patients were analyzed retrospectively and the surgical outcomes were evaluated.</p><p><b>RESULTS</b>No perioperative deaths occurred in these cases. Eight patients (5 with anastomosis, 2 with balloon dilation, and 1 with stent implantation) were lost to the follow-up ranging from 1 to 204 (mean 44.94-/+54.56) months. Of the patients available to the follow-up, 12 had airway restenosis, including 2 receiving end-to-end anastomosis (9.5%), 6 (50%) receiving balloon angioplasty, and 6 with granulation hyperplasia following stent implantation (50%). Of the 3 treatment, end-to-end anastomosis was associated with the lowest restenosis rate (Chi2=8.869, P=0.012).</p><p><b>CONCLUSION</b>End-to-end anastomosis, with a low postoperative restenosis rate and better prognosis, should be the primary choice for treatment of tracheal airway stenosis.</p>

Clinical analysis of primary thymic lymphoma: a report of 27 cases / 南方医科大学学报

<p><b>OBJECTIVE</b>To investigate clinicopathologic features and optimal treatment of primary thymic lymphoma.</p><p><b>METHODS</b>Clinical records of 27 primary thymic lymphoma patients treated from 1990 to 2007 were reviewed.</p><p><b>RESULTS</b>Of the 27 patients, 8 received mastectomy and chemotherapy, 12 received excision of the thymic lesion and chemotherapy, 5 received chemotherapy alone, and 2 received lesion excision alone. 24 achieved complete remission after scheduled treatment, 1 achieved partial remission, and 2 patients had progressive disease. With a follow-up of 10 years and median 38 months, the 5-year overall and disease-free survival rates of the 27 patients were 47% and 23% respectively.</p><p><b>CONCLUSION</b>The main subtypes of primary thymic lymphoma are diffuse large B-cell lymphoma and peripheral T-cell lymphoma. The optimal sequence is radical operation followed by standard anthracycline-based regimens and radiotherapy.</p>

The pathologic and clinic characteristics of papillary urothelial neoplasm with low malignant potential / 肿瘤

Objective: To discuss the pathologic and clinical characteristics of papillary urothelial neoplasm with low malignant potential (PUNLMP). Methods: We retrospectively analyzed 41 cases of PUNLMP confirmed by pathological examination from 2003 to 2006 and selected 28 cases of urothelial papilloma and 51 cases of low-grade papillary urothelial carcinoma as control. Results: Forty one cases of PUNLMP (male 31; female 10, ranging from 33 to 87 years, average 61.6 years) were recruited in this study. Recurrence occurred in 6 cases (15%) with the mean recurrence period of 24.6 months. No progression was detected by pathological examination. Four patients had multiple tumors, among them 2 (50%) cases recurred. In 28 cases of urothelial papilloma, recurrence was observed in 1 (4%) case with no progression. In 51 cases of low-grade papillary urothelial carcinoma, 18 (35%) cases experienced recurrence and 5 cases (10%) had progressed disease. The difference in recurrence rate among the three groups was significant (P = 0.002). Conclusion: PUNLMP has its own pathologic and clinical characteristics. The term "low maligant potential" is more appropriate than "carcinoma". Long-term follow-up is needed after surgery because of high recurrence rate.

Surgical treatment of 486 cases of adrenal gland diseases: a retrospective study / 中华外科杂志

<p><b>OBJECTIVE</b>To evaluate the roles of laparoscopic adrenalectomy (LA) and open adrenalectomy (GA) for treatment of adrenal gland diseases.</p><p><b>METHODS</b>The data of 486 patients with adrenal gland diseases was analyzed retrospectively during 5 years. A total of 478 patients received surgical treatments including 318 GAs and 160 LAs. The operation time, bleeding volume during operation, intestine function recovery time, pain postoperatively, hospital stay time postoperatively and postoperative complications in group GA and group LA respectively were compared.</p><p><b>RESULTS</b>All cases in group GA were successful. A total of 154 cases in group LA were successful, and 6 cases were converted to open surgery. In group LA, there were 9 cases whose tumor diameter exceeded 6 cm. There were 3 malignant cases in group LA, and no recurrence and metastasis were observed during 3-20 months follow-up. The average operation time was (112 +/- 16) mmn and (69 +/- 10) min in group GA and LA respectively. The average bleeding volume during operation was (286 +/- 23) ml, (56 +/- 10) ml in group GA and LA respectively. The average intestine function recovery time was (66 +/- 7) h, (24 +/- 7) h in group GA and LA respectively. The average frequency of treatment of pain was 1.9 +/- 0.4 and 0.5 +/- 0.1 in group GA and LA respectively. The average hospital stay time postoperatively was (10.3 +/- 1.1) d and (7.2 +/- 0.7) d in group GA and LA respectively. The rate of postoperative complications was 40.3% and 7.5% in group GA and LA respectively. All differences were significant (P = 0.023, 0.007, 0.039, 0.003, 0.029 and 0.001).</p><p><b>CONCLUSIONS</b>LA has the added benefit of shorter convalescent times, improving patients satisfaction and less associated complications, as it has proved to be as effective as OA.</p>

Experimental research on human spermatozoa membrane proteins by two-dimensional gel electrophoresis / 中华男科学杂志

<p><b>OBJECTIVES</b>To analyze human spermatozoa membrane proteins by two-dimensional gel electrophoresis and to provide a basis for drawing the protein map of normal human spermatozoa membrane proteins.</p><p><b>METHODS</b>Spermatozoa were purified by Percoll density centrifugation, and spermatozoa membrane proteins were analyzed by two-dimensional gel electrophoresis using isoelectric focusing and polyacrylamide gel electrophoresis.</p><p><b>RESULTS</b>About 800 protein spots could be identified by the imaging analysis system. The molecular weight and isoelectric point of most proteins were 20,000 to 100,000 and 3.0 to 7.0 respectively.</p><p><b>CONCLUSIONS</b>There are more than 800 types of proteins in the human spermatozoa membrane. The spermatozoa membrane protein can be identified with a certain precision by two-dimensional gel electrophoresis.</p>