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Acta Physiologica Sinica ; (6): 595-603, 2023.
Artigo em Chinês | WPRIM | ID: wpr-1007775

RESUMO

Parkinson's disease (PD) is a common neurodegenerative disease characterized by motor symptoms, including bradykinesia, resting tremor, and progressive rigidity. More recently, non-motor symptoms of PD, such as pain, depression and anxiety, and autonomic dysfunction, have attracted increasing attention from scientists and clinicians. As one of non-motor symptoms, pain has high prevalence and early onset feature. Because the mechanism of PD-related pathological pain is unclear, the clinical therapy for treating PD-related pathological pain is very limited, with a focus on relieving the symptoms. This paper reviewed the clinical features, pathogenesis, and therapeutic strategies of PD-related pathological pain and discussed the mechanism of the chronicity of PD-related pathological pain, hoping to provide useful data for the study of drugs and clinical intervention for PD-related pathological pain.


Assuntos
Humanos , Doença de Parkinson/terapia , Doenças Neurodegenerativas , Doenças do Sistema Nervoso Autônomo/complicações , Ansiedade , Dor/etiologia
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