Thyroid autoantibodies in euthyroid women with a history of recurrent miscarriage

To determine the prevalence of thyroid autoantibodies in women with a history of recurrent miscarriage, this study was carried out on twenty euihyroid women with a history of recurrent abortion and attending the Obstetrics and Gynecology Department of Tanta University Hospital. All serum samples were evaluated for the presence of thyroid peroxidase and thyroglobulin antibodies with the use of a standard, highly sensitive ELISA. Results of this study showed that 35% of women in the study group and 20% of women in the control group had positive assay results for either one or both of the thyroid autoantibodies. This means that thyroid autoantibodies were detected more frequently in women with recurrent miscarriage than in normal fertile women, and thus these antibodies can help in the detection of at risk pregnancy

Single intrauterine insemination versus double intrauterine inseminations at differnt timing in controlled ovarian hyperstimulation cycles

The use of controlled ovarian hyperstimulation[COH] in combination with intrauterine insemination [IUI] has gained acceptance as a valuable method of infertility treatment. This study was done to compare the effectiveness of a single periovulatory IUI with double IUI and to determine the optimal timing of double IUI in relation to human chorionic gonadotropin [hCG] administration in COH cycles. Thirty infertile couples with unexplained infertility were enrolled in our study and were classified into three groups, ten couples in each group. After COH with clomiphene citrate and gonadotropins, patients in group A received a single IUI performed 34 hours after hCG administration, patients in group B received double IUI performed 34 hours and 60 hours after hCG administration and patients in group C received double IUI performed 18 hours and 42 hours after hCG administration. Each regimen was tried in patients for three successive COH cycles. The pregnancy rate in group A, group B and group C were 20%, 20% and 40% respectively in relation to number of patients, and 7.7%, 7.4% and 16.7% respectively in relation to number of treatment cycles. This means that double IUI performed at 18 hours and 42 hours after hCG administration in COH cycles is the most cost- effective regimen for patients with unexplained infertility