Expression of transgelin-2 and clinical significance in colorectal cancer / 中华外科杂志

<p><b>OBJECTIVES</b>To investigate the relationship between the expression of transgelin-2 and the clinicopathological factors of colorectal carcinoma and evaluate the value of transgelin-2 in prognostic assessment of the colorectal cancer patients.</p><p><b>METHODS</b>Using tissue microarray and immunohistochemical methods, we examined transgelin-2 of 120 colorectal cancer patients received surgical treatment from September 2002 to April 2004, including 74 male and 46 female, age from 26 to 89 years. Analyzed the relationship between transgelin-2 and both the clinicopathological features and prognosis of the colorectal cancer by using χ² test and Kaplan-Meier survival analysis. Cox proportion hazard regression analysis was used to study the independent prognostic factors.</p><p><b>RESULTS</b>The positive rate of transgelin-2 expression was 69.2% in colorectal carcinoma. The transgelin-2 expression correlated with differentiation degree (χ² = 5.420), lymph nodes metastasis (χ² = 45.577), distant metastasis (χ² = 12.009), and TNM staging (χ² = 47.577). The survival time was (39 ± 5) months in patients with positive expression of the transgelin-2, while (59 ± 3) months in patients with negative expression. The patient's survival time was statistically correlated with the transgelin-2 expression (P = 0.003). Distant metastasis (RR = 8.318, 95%CI: 4.119 - 16.790), lymph nodes metastasis (RR = 2.794, 95%CI: 1.246 - 6.263) and transgelin-2 expression (RR = 1.834, 95%CI: 1.118- 2.973) were independent prognostic factors in patients with colorectal cancer (P < 0.05).</p><p><b>CONCLUSIONS</b>The expression of transgelin-2 is correlated with clinicopathological features and prognosis in colorectal cancer, may be the potential marker of metastasis and the prognosis of colorectal cancer patients.</p>

A clinical study on the degree of mesorectal tumor invasion in middle-low rectal cancer / 中华胃肠外科杂志

<p><b>OBJECTIVE</b>To study the relationship between the degree of mesorectal tumor invasion and prognosis of the patients with middle-low rectal cancer.</p><p><b>METHODS</b>Specimens from 49 patients with middle-low rectal cancer, undergone total mesorectal excision in our hospital from April 2003 to December 2003,were studied by large slice pathologic technique. The thickness of mesorectum and the depth of tumor infiltration were measured, and the degree of mesorectal tumor invasion was calculated. The local recurrence rate, metastasis rate and 5-year survival rate were investigated respectively. Possible clinicopathological influence factors were also analyzed.</p><p><b>RESULTS</b>The local recurrence rate was 12.2%(6/49), the distant metastasis rate was 26.5%(13/49). In three different degrees of mesorectal tumor invasion(I(,II(,III(), the local recurrence rates were 0, 7.7% and 31.3% (chi(2)=7.357, P =0.015); the metastasis rates were 10%, 23.1% and 50%(chi(2)=7.405, P =0.025); the 5-year survival rates were 90.9%, 69.2% and 28.6%(log-rank, P =0.013). Tumor diameter, T and N staging were risk factors influencing the degree of mesorectal tumor invasion(chi(2)=6.849 P=0.033, chi(2)=34.845 P =0.000, chi(2)=17.266 P =0.002).</p><p><b>CONCLUSIONS</b>The degree of mesorectal tumor invasion is an important predictor of local and distant metastasis as well as survival of patients in middle-low rectal carcinoma. The degree of mesorectal tumor invasion in the middle-low rectal carcinoma is significantly correlated with tumor diameter, T and N stage.</p>

Study on the tumor infiltration in mesorectum of rectal cancer by spiral computed tomography and histopathology / 中华外科杂志

<p><b>OBJECTIVE</b>To evaluate the value of spiral computed tomography in the preoperative assessment of the degree of tumor infiltration in mesorectum and circumferential resection margin status of rectal cancer compared with large tissue slice technique.</p><p><b>METHODS</b>Fifty-seven patients with rectal cancer diagnosed by fiber colonoscopy and pathology from March 2007 to December 2007 underwent preoperative 64-layers spiral CT examination. The degree of tumor infiltration in mesorectum and circumferential resection margin status were evaluated. Large tissue slice technique was applied in the pathologic study after the total mesorectal excision of the rectum to determine the degree of tumor infiltration in mesorectum and the circumferential resection margin status. The spiral CT findings were compared with pathologic results. The accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the CT results were assessed respectively.</p><p><b>RESULTS</b>The overall spiral CT accuracy was 93.0% (53/57) for the degree of tumor infiltration in mesorectum, and it was 94.7%, 94.7% and 96.5% for degree I, II, III infiltration, respectively. Fifty-three cases (93.0%) were accurately predicated with the circumferential resection margin status. The sensitivity, specificity, PPV and NPV of spiral CT measurement was 80.0%, 97.6%, 92.3% and 93.2%, respectively, and was consistent well with the histopathological diagnosis.</p><p><b>CONCLUSIONS</b>Spiral CT provides accurate preoperative assessment for the degree of tumor infiltration in mesorectum and circumferential resection margin status of rectal cancer.</p>