Near and distance stereopsis restoration in amblyopia with S3D computer treatment / 国际眼科杂志(Guoji Yanke Zazhi)

AIM: To evaluate the effect of stereoscopic 3D (S3D) technology as a visual training system in children with amblyopia. METHODS:Totally 30 children,aged 4-16 years old,18 with ametropic amblyopia ( AMA ), and 12 with anisometropic amblyopia(ANA) were recruited in this study. A binocular 3D shutter glasses technology visual training system was used for training trials. Each training time lasted 1h,and the number of training trials totaled 33 (mean士SD:32士8) times on average,per-person. Before and after each training trial, the best corrected visual acuity ( BCVA) of each eye, range of fusion by synoptophore, as well as near and distance stereopsis acuity by Yan Shaoming random - dot test and synoptophore respectively was measured. RESULTS: A significant difference was found pre- and post treatment in BCVA in both kinds of amblyopia studied. Significant improvement was also found in fusion range and stereopsis acuity. The improvement of fusion range and stereopsis recovery could be seen in ANA than in AMA patients. The near stereopsis acuity recovery in ANA group might more easily to regain stereoacuity at near than in AMA group. CONCLUSION: S3D display vision training systems are indicated for the recovery of stereoacuity in children with amblyopia.

GATA-3 expression in the development of anterior chamber associated immune deviation / 中华医学杂志(英文版)

<p><b>BACKGROUND</b>Anterior chamber associated immune deviation (ACAID) is characterized by a Th2 cell response. GATA-3 has been shown to be necessary for the activation of Th2 cells. This study was designed to examine the expression of GATA-3 in the development of ACAID.</p><p><b>METHODS</b>ACAID was induced by injection of 50 microg interphotoreceptor retinoid binding protein (IRBP) into the anterior chamber (AC) of Wistar rats. Delayed-type hypersensitivity (DTH) was evaluated on day 3, 7, 14, 21, 28 after IRBP inoculation. GATA-3 expression was detected using immunohistochemical staining. The expression of GATA-3 mRNA at different time points after AC injection of IRBP was assayed by reverse transcriptase polymerase chain reaction (RT-PCR).</p><p><b>RESULTS</b>A significant DTH reaction was observed in Wistar rats on day 3 and 5 after IRBP inoculation. The DTH reaction was decreased 7 days after IRBP inoculation. GATA-3 expression was weak at both mRNA and protein levels in the normal spleen, but was significantly increased on day 5, 7, 14, and 21 after AC injection of IRBP.</p><p><b>CONCLUSION</b>The expression of GATA-3 is increased during ACAID, suggesting that GATA-3 may be involved in the development of ACAID.</p>