Synthesis and antibacterial and antifungal effects of 5-fluoroisatine and derivatives

The Sandmeyer isatin synthesis consisting of the condensation of primary arlamines with chloral and hydroxylamine to the corresponding isonitrosoacetanilides, and subsequent cyclization of the latter, was now applied with success to p-fluoroaniline, which gave 5-fluoroisatin (I). On treatment with the appropriate aryhydrazine compound I gave 3- aryhydrazine-fluoroisatin (II-VII). By the condensation of I with various p-X-C6H4NH2 compounds, 4 derivatives (VIII-XI) were formed. All synthesized compounds have been characterized by their IR and elemental analysis. 7 synthesized compounds (I-VII) were tested for biological activities such as antibacterial and antifungal. Among these, compounds I showed an antibacterial on 8 strains of bacteria and an antifungal activity against candidia albicans. compound VI showed an antibacterial activity on 2 strains of bacteria and an antifungal activity against candidia albicans.

Synthesis and antibacterial and antifungal properties of base N-Mannich of 5-fluoroisatin-3-arylimin

By the condensation of 5-fluoroisatin with various p-X-C6H4NH2 compounds, 4 derivatives (I-IV) were formed. Compounds (I-IV) underwent Mannich reaction and gave V-XII with formaldehyde (36% aqueous solution) and secondary amine (morpholine and piperidine). All synthesized compounds hade been characterized by IR, MS and elemental analysis. All synthesized compounds (I-XII) were tested for biological activities such as antibacterial and antifungal. Among them, compound V showed an antibacterial activity on 6 strains of bacteria. Compound IX and X showed an antibacteria and antifungal activity against Candida albicans... Compound VI showed an antibacterial activity on 3 strains of bacteria. Compound XI and XII showed an antibacterial activity on 2 strains of bacteria.

Analysis of drugs with several components by UV-VIS MCA spectrophotometric technique - An application of informative industry in drug control

Some algorithms used in UV-Vis MCA spectrophotometry technique and some recent statistical approaches to the Advanced MCA technique were described. A number of pharmaceutical formulas containing 2-4 ingredients has been analyzed successfully using MCA technique. Basing on the basic algorithm of MCA and its statistical approaches, an applicable software for data processing had been established (running in Windows (environment - IBM compatible computer). This enables to use MCA technique for conventional spectrophotometers.

Synthesis and antimicrobial and antifungal activities of Base N-Mannich of 5 fluorosatin and their derivatives

Synthesis and antibacterial and antifungal effects of some N-Mannich base of 5-fluoroisatin and their derivatives 5-fluoroisatin (I) has been prepared by the method of Sandmeyer (1919). Compound (I) underwent Mannich reaction and gave II, X with formaldehyde (36% aqueous solution) and secondary amine (morpholine and piperidine). On treatment with the appropriate arylhydrazines, compound II gave 3-arylhydrazino-5-fluoro-1-morpholinomethyl isatin (III-IX), compound X gave 3-arylhydrazino-5-fluoro-1-piperidinomethyl asatin (XI-XVI). All synthesized compounds have been characterized by IR, MS, 1H.NMR and elemental analysis. All synthesized compounds (I-XVI) were tested for biological activities such as antibacterial and antifungal. Among these, compounds I, II, X showed an antibacterial activity against Candida albicans. Compound XIII showed an antibacterial activity on 6 strains of bacteria. Compound XIV showed an antibacterial activity on 4 strains of bacteria. Compound V showed an activity on 2 strains of bacteria and compound XV showed an antibacterial activity on 1 strain of bacteria.

Evaluation of the situation of utilization of chemicals for vegetal protection in cultivation of medicinal plants at an area for this cultivation in Hung Yen province

The initial investigation of pesticides using cultivation of medical plants in ThietTru, BinhMinh, KhoaiChau, HungYen was reported. Almost pesticides in common use for cultivation of medicinal plants there were recorded and classified. The results of investigation showed that they were often used extensively and in a wrong way. although the Organo-chlorine pesticides (except endosulfan) were no longer in use but at least one prohibited pesticide (methamidophos) were still illegally overused. Further investigation in broader areas for some other localities should be undertaken for systematical evaluation of pesticides use in the cultivation of medicinal plants, and especially its impact. Residual pesticides in herbal medicines should be determined as well, since then, some active measure of management and method of control will be proposed in order to strengthen the quality assurance of this precious resource of medicines.

Synthesis and antibacterial, antifungal effects of 5-bromo-1-morpholinomethyl isatin and derivatives

By bromation of isatin, 5-bromoisatin (I) was obtained. Compound (I) underwent Mannich reaction and gave II with formaldehyde (36% aqueous solution) and morpholine. On treatment with the appropriate arylhydrazines, compound II gave 3-arylhydrazino-5-bromo-1-morpholinomethyl isatin (III-VIII). All synthesized compounds have been characterized by their IR, elemental analysis (II was characterized by MS, 1H.NMR). All synthesized compounds (I-VIII) were tested for biological activities such as antibacterial and antifungal. Among these, compounds I, II showed an antibacterial activity on 8 strains of bacteria

Synthesis and biological effects of N-hydroxy-methyl-5-bromoisatine and derivatives

By bromation of isatin 5-bromoisatin (I) was obtained. On boiling (I) with 4% formaldehyde solution for short period of time, a compound was isolated which has been characterized as N-hydroxymethyl-5-bromoisatin (II). By condensation of I with various H2N-B compounds, 6 derivatives (III-VIII) were formed. The structures of the obtained products were characterized by IR spectroscopy (II was characterized by MS, 1H.NMR). The synthesized compounds were tested for biological activities such as antibacterial and antifungal. Among these, two compounds (I, II) showed an antibacterial activity on 8 strains of bacteria. Compound VI showed an antibacterial activity on 3 strains of bacteria. Compound VI showed an antibacterial activity on 3 strains of bacteria.