Trail to induce psoriatic skin lesion in the skin of BALB/C mice by injection of Staphylococcus aureus exotoxin

An In Vivo attempt to induce psoriatic lesions in the skin of BALB/C mice by injection of bacterial superantigen. Staphylococcus aureus that was isolated from skin lesions of psoriatic patients was subjected to gel filtration chromatography for extraction and purification of their exoproteins. The skin of BALB/C mice was injected by 0.2 ml of the extracted purified exo toxin. The induced lesions were markedly similar to that of human psoriatic lesions, although the histopathological changes were not completely mirrored to that of human psoriatic skin lesions. There is an important role of Staph. aureus exotoxin [superantigen] in induction, triggering and maintenance of psoriatic lesions

Severe perinatal asphyxia: incidence, risk facrors and short-term outcome in a regional hospital in Oman

This study was aimed to document the incidence, risk factors and short-term outcome of severe perinatal asphyxia in a regional referral hospital in Oman. Of the 7487 babies delivered in our hospital during a 3-year period [1999-2001], 61 [8.2 per thousand] suffered severe perinatal asphyxia. Twenty One other severely asphyxiated babies, delivered elsewhere, were referred to us for care. The identified risk factors in all these 82 babies comprised mainly of complications of labour or delivery [in 53 babies, 66%], low birth weight [in 24 babies, 29%] and maternal disease [17 instances, 21%]. Some babies had multiple risk factors. Eighteen [22%] of the babies died, 15 [18%] survived but with residual neurodeficit, while 49 [60%] survived apparently intact. Predictors of an adverse outcome included an Apgar score of zero at one minute, or less than 4 at 5 minutes, low birth weight, and cerebral oedema or haemorrhage. Infants of primiparous mothers also fared poorly. We conclude that perinatal asphyxia is still a significant problem in our practice area. Many of the risk factors are potentially preventable. But attainment of that goal requires sustained health education, continuing improvements in the health services, and a change in societal attitude, especially in terms of reproductive demands on women

Severe perinatal asphyxia: Incidence, risk factors and short-term outcome in a regional hospital in Oman

This study was aimed to document the incidence, risk factors and short-term outcome of severe perinatal asphyxia in a regional referral hospital in Oman. Of the 7487 babies delivered in our hospital during a 3-years period [1999-2001], 61 [8.2 per thousand] suffered severe perinatal asphyxia. Twentyone other severely asphyxiated babies, delivered elsewhere, were referred to us for care. The identified risk factors in all these 82 babies comprised mainly of complications of labour or delivery [in 53 babies, 66%], low birth weight [in 24 babies, 29%] and maternal disease [17 instances, 21%]. Some babies had multiple risk factors Eighteen [22%] of the babies died, 15 [18%] survived but with residual neurodeficit, while 49 [60%] survived apparently intact. Predictors of an adverse outcome included an Apgar score of zero at one minute, or less than 4 at 5 minutes, low birth weight, and cerebral oedema of haemorrhage. Infants of primiparous mothers also fared poorly. We conclude that perinatal asphyxia is still a significant problem in our practice area. Many of the risk factors are potentially preventable. But attainment of that goal requires sustained health education, continuing improvements in the health services, and a change in societal attitude, especially in terms of reproductive demands on women

out come of primary nerve repair at the forearm

Eighteen injured peripheral nerves at the forearm level were repaired primarily either by immediate or by delayed primary repair according to the mechanism of injury, the presence of contamination and /or skin loss. Nine nerves were cut sharply and were immediately repaired of which four nerves achieved excellent results, three achieved good results and the results were poor in the remaining two nerves. In nine nerves, there were laceration, contamination and /or skin loss and they were repaired by delayed primary neuropathy after one week from the time of injury. Two nerves achieved excellent results, five nerves achieved good results and two nerves achieved poor results

Effect of different nutrient elements on course, susceptibility and development of Hymenolepis nana infections

This experimental study was carried out to assess the role of some nutrient elements on mice infected with H. nana. The results obtained showed that: Vitamin A deficient diet was unsuitable for growth of mice and also unsuitable for the parasite as evidenced by marked decrease in the number of viable egg count as compared with the control. However, worm burden was not affected. Vitamin B complex deficient diet was unsuitable for growth of mice and also unsuitable for the parasite as evidenced by marked reduction in number of worms recovered and marked decrease in percentage of viable eggs in stools as compared with the control. Vitamin D deficient diet did not influence H. nana infection. Protein deficient diet promoted H. nana infection, whereas the percentage of viable eggs was markedly decreased. High protein diet provided the host with protective properties and led to suppression of H. nana infection. Standard diet favored normal development of both host and parasite ending in a state of equilibrium between them

Therapeutic trial in idiopathic oligospermia: principal results

This work was undertaken to investigate the pharmacological intervention in Management of idiopathic oligospermia. Thirty patients, were either on Cyclofenil, Mesterolone, Gonadotrophin or vitamin E therapy enrolled in this study. Our results showed these agents induced a variable effects in sperm count and motility, and a successful pregnancy was reported in one out of seven cases treated with cyclofenil. We conclude this pharmacological effect of these drugs in idiopathic oligospermia is not effective and of temporary nature. More research is needed to find a better and effective approach to the management of idiopathic oligospermia