Expression of P27 in prostatic adenocarcinoma

The objective of this study was to evaluate p27 expression in prostatic adenocarcinoma and to assess its association with some morphologic and clinical features. A sample of 69 specimens of prostatic adenocarcinoma were evaluated for p27 expression by quantifying nuclear immunohistochemical staining, p27 expression was tested for association with patient age, family history of prostate cancer and preoperative serum prostate-specific antigen level, p27 expression was analyzed as a continuous variable and the tumors were classified as low expressors [<50% of cells p27 positive] or high expressors [>50% of cells p27 positive] for comparison. Patients with adenocarcinoma that exhibited low p27 expression had higher mean Gleason scores than did high expressors [7 vs. 6.2, respectively]. The evaluation of p27 expression might provide additional prognostic information

Angiogenesis as a prognostic marker for carcinomas of the urinary bladder

To verify the relationship of tumor angiogenesis with some histopathological variables [tumor grade, stage and nodal metastasis] and prognosis in the different types of urinary bladder carcinoma, 33 radical cystectomy specimens were evaluated for angiogenesis using manual quantification technique of microvessel density [MVD] after immunohistochemical staining of vascular endothelium using an antibody for factor VIII-related antigen. The study involved different glades of bilharzial and non-bilharzial squamous cell carcinoma [SCC], transitional cell carcinoma [TCC] and adenocarcinoma of the urinary bladder. A significant relationship was found between tumor angiogenesis and the histopathological variables in both of bladder SCC and TCC. In bladder adenocarcinoma significant relationship was found between angiogenesis and each of tumor grade and presence of lymph node metastasis