Biochemical changes during a cross-over treatment of doxazosin, moduretic and amlodipine in hypertensive patients

A cross-over study was done to compare the effects of doxazosin, moduretic and amlodipine on biochemical values in 9 hypertensive Nigerians aged 35 to 65 years. Doxazosin therapy was characterized by significant increase in the levels of mean plasma total protein and albumin, while moduretic therapy showed significant reduction in the mean values of plasma creatinine and calcium. All other parameters did not show any significant variation during doxazosin and moduretic treatment phases; and amlodipine therapy did not have any effect on the biochemical values of the hypertensive patients

Changes in lipid and lipoprotein values during a cross-over treatment of doxazosin, moduretic and amlodipine in hypertensive patients

A cross-over study, comparing the effects of doxazosin, moduretic and amlodipine on plasma lipid and lipoprotein levels in 9 hypertensive Nigerians aged 35 to 65 years is presented. Doxazosin therapy had favourable lipid changes characterized by a statistically significant reduction in total cholesterol [TC] at 6 months. Though consistent reduction was observed in total triglycerides [TG] low density lipoprotein cholesterol [LDL-C], very low density lipoprotein-cholesterol [VLDLC] upto 6 months, no effect was seen on high density lipoprotein cholesterol [HDLC]. This is against unfavourable increments in the mean values of TC, VLDLC, LDLC/HDLC and decrease in HDLC/TC during moduretic treatment phase. Amlodipine therapy did not alter the lipid and lipoprotein levels. The non-significant variation in the mean high density lipoprotein-cholesterol [HDLC] level observed with these agents, seem to suggest that HDL-cholesterol metabolism may be maintained during antihypertensive pharmacotherapy

Abnormal lipid and lipoprotein patterns in liver cirrhosis with and without hepatocellular carcinoma

Plasma lipid and lipoprotein profile was determined in 12 cirrhotics, 15 patients with cirrhosis and hepatocellular carcinoma [HCC] and 20 healthy volunteers. When compared with controls plasma total cholesterol [TC], high density lipoprotein cholesterol [HDLC], high density lipoprotein phospholipids [HDLPL], HDLPL/PL levels were low, phospholipid [PL] was normal and HDLC/TC and PL/TC were high in cirrhosis. In cirrhotics with HCC, TC, PL, PL/TC levels were elevated while HDLC, HDPL, HDLC/TC and HDLP/PL were normal. A comparison within the patient groups showed that in cirrhosis alone, the levels of TC, HDLC, PL, HDLPL and HDLPL/PL were lower and PL/TC level was higher than in cirrhotics with HCC. Plasma albumin levels showed a negative correlation with PL/TC and a positive correlation with HDL-cholesterol in cirrhosis. In cirrhosis with HCC plasma, phospholipid levels showed a significant negative correlation with total bilirubin and alanine aminotransferase. The variations in the level of plasma lipids and lipoproteins may assist in describing the nature of these two forms of liver disease