RESUMO
In the study, to analyse a K-ras oncogene mutated at codon 12 in 24 patients with cholangiocarcinomas, four (16.67%) of them contained this point mutation. One of 4 was peripheral and the others were hilar tumors. There was no significant relationship between mutation and clinical features in terms of age, sex, endemic area, tumor location, tumor grading and pathological features. In our study, the incidence of K-ras codon 12 mutation in Thai patients with cholangiocarcinoma was lower than that found in British and Japanese patients. The discrepancy of incidence and type of the mutations, in different races and environment probably indicates that there is/are different etiologic mechanism(s) in the pathogenesis of cholangiocarcinoma.
Assuntos
Adulto , Idoso , Idoso de 80 Anos ou mais , Sequência de Bases , Neoplasias dos Ductos Biliares/genética , Ductos Biliares Intra-Hepáticos , Colangiocarcinoma/genética , Códon/genética , Intervalos de Confiança , DNA de Neoplasias/análise , Feminino , Genes ras/genética , Humanos , Masculino , Pessoa de Meia-Idade , Dados de Sequência Molecular , Mutação Puntual/genética , Reação em Cadeia da Polimerase , Sensibilidade e EspecificidadeRESUMO
A case of subcutaneous gnathostomiasis in which subsequently a gnathostome larva crept out through a surgical wound in a 22-year-old Thai male is described. This case disclosed that although a worm may creep out of the body through certain natural passages as well as the skin, spontaneous exit via a surgical wound is a possibility. Based on the morphology and number of the head-bulb hooklets and cuticular spines by light and electron microscopy and gnathostome was confirmed as a third stage larva of gnathos toma spinigerum.