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China Journal of Chinese Materia Medica ; (24): 1257-1260, 2006.
Artigo em Chinês | WPRIM | ID: wpr-356730

RESUMO

<p><b>OBJECTIVE</b>To research the effect of glaucocalyxin A (GLA) on the level of Th1/Th2 type cytokines in mice.</p><p><b>METHOD</b>By using flow cytometer with CBA software to detect Th1/Th2 type cytokines.</p><p><b>RESULT</b>GLA had insighificant inhibitory effects on Th1 and Th2 cytokines (IL-2, IFN-gamma,TNF-alpha, IL-4 and IL-5) induced by ConA, in which more potential on cytokines from Th1 than those of from Th2 were displayed. However, GLA could produce inhibition on IL-2, IFN-gamma and TNF-alpha and acceleration on IL-4 and IL-5.</p><p><b>CONCLUSION</b>Immunosuppressive effect of GLA is related to the influence the level of Th1/Th2 type cytokines.</p>


Assuntos
Animais , Feminino , Masculino , Camundongos , Citocinas , Metabolismo , Diterpenos do Tipo Caurano , Medicamentos de Ervas Chinesas , Farmacologia , Interferon gama , Metabolismo , Interleucina-2 , Metabolismo , Interleucina-4 , Metabolismo , Interleucina-5 , Metabolismo , Isodon , Química , Camundongos Endogâmicos BALB C , Plantas Medicinais , Química , Células Th1 , Metabolismo , Células Th2 , Metabolismo , Fator de Necrose Tumoral alfa , Metabolismo
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