A case of a 107-year-old elderly COVID-19 patient infected with Omicron variant BA.5.1.3 in Hainan / 中国热带医学

@#Abstract: Objective　This article summarizes the clinical characteristics and diagnosis and treatment experience of an elderly patient infected with Omicron variant BA.5.1.3 of COVID-19 in Hainan Province. Methods　The clinical data and treatment of an elderly patient infected with Omicron variant BA.5.1.3 of COVID-19 admitted to Haikou designated hospital on August 15, 2022 were retrospectively analyzed. Results　A 107-year-old female patient was admitted to the hospital with "fever and cough for 1 day". Two of her family members have infected with COVID-19. The patient initially developed fever, accompanied by cough, expectoration, a little white sticky sputum, accompanied by sore throat, muscle pain, fatigue. Nucleic acid test was positive in throat swab, indicating Omicron variant BA.5.1.3 infection. The patient was diagnosed as mild COVID-19 and treated with antiviral therapy, Chinese medicine conditioning, anticoagulation, electrolyte disorder regulation and symptomatic treatment for 9 days. The patient's clinical symptoms were relieved, and she was cured and discharged after two negative nucleic acid tests. One week later, the patient recovered well. Conclusions　Omicron variant BA.5.1.3 is highly infectious, and comprehensive treatment such as antiviral treatment and traditional Chinese medicine treatment has achieved good efficacy. For elderly patients, attention should be paid to maintaining the stability of organ function and internal environment, which is helpful to improve the prognosis of patients.

Physical training system associated with strengthening of the core in young swimmers / Sistema de treinamento físico associado ao fortalecimento do core em jovens nadadores esportistas / Sistema de entrenamiento físico asociado al fortalecimiento del core en jóvenes nadadores

ABSTRACT Introduction: CORE fitness training in athletes is intimately related to their performance in competitive sports. However, few academic studies are dedicated to investigating this relationship in young swimmers. Objective: Verify the association between supplementary physical training focused on the CORE in young swimmers and their athletic performance. Methods: Randomized controlled study with 20 swimmers (12 males) born post-2000 was made in aquatic training three times a week for six months. The experimental group received a specific exercise protocol with emphasis on the CORE. The physiological comparison of the data considered the total time to complete the 400 and 800-meter freestyle swim. Results: After six months, the control group obtained a reduction of 2.6s versus 3.2s of the experimental group in the 400-meter freestyle swim; performance in the 800 meters revealed a reduction of 1s for the control group versus 4.5s of the experimental group, compared to the initial measurement. Conclusion: Supplemental fitness training focused on the CORE in young swimmers is positively associated with improvements in their athletic performance. Evidence Level II; Therapeutic Studies - Investigating the results.

RESUMO Introdução: O treinamento da aptidão física do CORE no atleta está intimamente relacionado com o seu desempenho nos esportes competitivos. Porém, ainda são poucos os trabalhos acadêmicos dedicados a investigar essa relação em jovens nadadores. Objetivo: Investigar a associação entre o treinamento físico complementar focado no CORE em jovens nadadores e seu desempenho atlético. Métodos: Estudo randomizado controlado com 20 nadadores (12 homens) nascidos após o ano 2000 sob treino aquático com frequência de 3 vezes na semana e duração de 6 meses. O grupo experimental recebeu um protocolo específico de exercício com ênfase no CORE. A comparação fisiológica dos dados considerou o tempo total para completar o nado em estilo livre de 400 e 800 metros. Resultados: Ao fim de seis meses, o grupo controle obteve uma redução de 2,6s contra 3,2s do grupo experimental no nado livre de 400 metros; a performance nos 800 metros revelou uma redução de 1s para o grupo controle contra 4,5s do grupo experimental, comparados a mensuração inicial. Conclusão: O treinamento complementar de aptidão física focado no CORE em jovens nadadores está positivamente associado com melhorias no seu desempenho atlético. Nível de evidência II; Estudos Terapêuticos - Investigação de Resultados.

RESUMEN Introducción: El entrenamiento de la aptitud física del CORE en el atleta está estrechamente relacionado con su rendimiento en el deporte de competición. Sin embargo, todavía hay pocos trabajos académicos dedicados a investigar esta relación en nadadores jóvenes. Objetivo: Investigar la asociación entre el entrenamiento físico complementario centrado en el CORE en jóvenes nadadores y su rendimiento deportivo. Métodos: Estudio controlado aleatorio con 20 nadadores (12 varones) nacidos después del año 2000 sometidos a un entrenamiento acuático con una frecuencia de 3 veces por semana y una duración de 6 meses. El grupo experimental recibió un protocolo de ejercicio específico con énfasis en el CORE. La comparación fisiológica de los datos tuvo en cuenta el tiempo total para completar los 400 y 800 metros de natación en estilo libre. Resultados: Después de seis meses, el grupo de control obtuvo una reducción de 2,6s frente a 3,2s del grupo experimental en los 400 metros de natación en estilo libre; el rendimiento en los 800 metros reveló una reducción de 1s para el grupo de control frente a 4,5s del grupo experimental, en comparación con la medición inicial. Conclusión: El entrenamiento físico complementario centrado en el CORE en jóvenes nadadores se asocia positivamente con mejoras en su rendimiento deportivo. Nivel de evidencia II; Estudios terapéuticos - Investigación de resultados.

Feasibility and safety of three periprocedure anticoagulation therapy in patients over 75 years ;undergoing radiofrequency ablation for atrial ifbrillation / 中国介入心脏病学杂志

Objective To observe the safety and efficacy of different periprocedural anticoagulation strategies in patients undergoing catheter ablation of atrial ifbrillation. Methods Eighty-five patients aged over 75 undergoing catheter ablation of atrial fibrillation from Jul 2011 to Nov 2013 were enrolled. They all took warfarin and transesophageal echocardiograms were performed to rule out left atrium appendage thrombus before ablation. They were divided into 3 groups. In Group 1 (30 cases), warfarin was stopped and bridged with low molecular weight heparin (LMWH) 3 days before procedure and LMWH bridging followed by warfarin alone after procedure. In Group 2 (32 cases), warfarin was continued during periprocedural period. In Group 3 (23 cases), Dabigatran or Rivaroxaban alone was used 4 hours after procedure respectively. Unfractionated heparin was used during procedure in all three groups. These three anticoagulation strategies were compared in bleeding, embolism events and other complications during 3-month follow-up. Results In Group 1, there were 1 new-onset ischemic stroke during hospitalization, 7 lower extremity hematomas, 1 subdural hemorrhage during 3-month follow-up and 6 minor bleeding events. In Group 2, there were 4 lower extremity hematomas and 4 minor bleeding events during 3-month follow-up. As for Group 3, only 2 lower extremity hematomas during hospitalization was observed in each without any minor bleeding events during follow-up. Conclusions Catheter ablation in elderly atrial ifbrillation patients was safe and effective in general. Compared with traditional anticoagulation strategy, continuing warfarin or novel oral anticoagulants could reduce bleeding complications without increasing thromboembolism risk.

Endothelial function and platelet activation in patients with non-valvular atrial fibrillation and the influence of beta-blocker on them / 中华老年医学杂志

Objective To examine the serum von Willebrand factor (vWF) and soluble Pselectin levels in patients with non-valvular atrial fibrillation (NVAF), and to observe the influence of beta-blocker treatment on endothelial function and platelet activation in NVAF patients. Methods The 25 subjects, 17 males and 8 females, with persistent NVAF and left ventricular ejection fraction (LVEF)≥50%, were enrolled in NVAF group. Those with myocardial infarction, cardiomyopathy or hyperthyroidism were excluded. Another 35 subjects with sinus rhythm were as control (age,gender and LVEF matched with NVAF group, and with similar cardiovascular diseases). Serum vWF and soluble P-selectin levels were tested by enzyme-linked immunosorbent assay. Results The serum vWF level was significantly higher in NVAF group than in control group [(1945.2±111.3) g/L vs. (1862.3±101.6) g/L, P＜0.05]. However, there was no significant difference in serum soluble P-selectin level between NVAF group and control group [(24.32±9.21) g/L vs. (24.68±11.70) g/L, P＞0. 05]. After administration of beta-blocker, a down-regulation was found in serum vWF level [(1758. 3±152. 4) g/L, P＜0. 01], but not in soluble P-selectin level [(21.05±8. 94) g/L, P＞0. 05]. There was no relationship between serum level of vWF and soluble P-selectin (r=-0.008,P＞0. 05). Conclusions High serum level of vWF is found in patients with persistent NVAF as compared with control, indicating endothelial damage/dysfunction in those patients. After administration of beta-blocker, serum level of vWF drops dramatically in NVAF patients, indicating possible endothelial function protection of beta-blocker.

Characterization of Orientia tsutsugamushi strains isolated in Shandong Province, China by immunofluorescence and restriction fragment length polymorphism (RFLP) analyses.

In order to identify the characteristics of the Sta56 gene of the 23 isolates of Orientia (O.) tsutsugamushi isolated in Shandong Province, indirect immunofluorescence assay (IFA) was used to identify the gene type of 23 strains O. tsutsugamushi isolated from scrub typhus patients, chigger mites, and rodents. Restriction fragment length polymorphism (RFLP) analysis was also used to analyze the restriction profiles of the Sta56 gene PCR amplification products of the 23 isolated strains of the O. tsutsugamushi; the results were compared with those acquired by nested PCR. By IFA, 21 of the 23 isolates belonged to the Gilliam type, and 2 to the Karp type. Using RFLP analysis, 21 strains had similar restriction profiles to the Japan Kawasaki strain, but they had no restriction site Hha I, and thus had some difference in gene sequence compared with the Japan Kawasaki strain. The other 2 strains had similar restriction profiles to Karp. These results were identical to that acquired by nested-PCR. In Shandong Province, the gene types of epidemic O. tsutsugamushi strains were similar to the Japan Kawasaki type, but had some differences in gene sequence. In addition, Karp also existed.