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The residents and low-grade resident trainees of the Department of Otorhinolaryngology Head and Neck Surgery of the Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine were selected as subjects. In the multi-touch virtual anatomy system, the lecturers made the anatomical signs of otolaryngology head and neck surgery, and applied them through the training method. Then the teachers explained the three sub-specialties of the nose, throat, neck and ear in the multi-touch virtual dissection table. The teaching method can stimulate the learning interest because of its vivid three-dimensional sense. The characteristics of teaching and learning are beneficial to the cultivation of medical education teachers. In addition, the one-time investment of equipment breaks through the supply bottleneck of traditional anatomical consumables and promotes active learning among medical students. The multi-touch virtual anatomy system can effectively improve the teaching methods, facilitate the interesting teaching, and has broad application prospects in medical teaching.
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Objective: To explore the features of the amplitude of low-frequency fluctuation (ALFF) in resting-state brain activity in children with idiopathic epilepsy (IE). Methods Totally 17 children with IE (IE group) and 14 matched controls (control group) were recruited. The structural and resting-state fMRI data were collected, and ALFF was computed with DPARSF software. The difference of ALFF between 2 groups was explored with the multivariate regression model, and the age and gender were considered as covariates. The correlation between ALFF and duration of disease was evaluated. Results Compared with control group, increased ALFF brain regions were observed in right brainstem, left cerebellum and parahippocampus in IE group, and reduced ALFF brain regions were observed in bilateral anterior cingulate gyrus, bilateral orbital frontal cortex, left superior frontal gyrus, left middle frontal gyrus, bilateral parietal lobule and bilateral angular gyrus (all P<0.05, 3dClustSim corrected). The multivariate regression analysis showed that ALFF in the right brainstem was positively correlated with the duration of IE (r=0.82, P<0.05, 3dClustSim corrected). Conclusion: The spontaneous brain activity in children with IE alters and associates with duration of disease. These findings may be evidences for elucidating potential neural mechanism of IE in childhood.
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Objective To investigate the dynamic images of traumatic penumbra(TP)in a rat model of traumatic brain injury (TBI)treated with AQP4-RNAi using multimodal MRI(MM-MRI)at 7.0 Tesla.Methods A rat model of TBI was established by the improved Feeney's method.MRI scans were performed including T2WI,DWI,ADC and SWI.The pathological changes in penumbra area were observed.All statistical analyses were performed using SPSS 21.0 software package.Results Over time rs-T2WI,rs-DWI and rs-SWI in TBI group were gradually increased.The r-ADC began to increase at one hour after trauma and reached the peak at 6 h. Then it began to fall and reached the bottom at 12 h.At each time point,the difference was statistically significant(P<0.05).Compared with RNA interference group,the rs-T2WI and rs-DWI in TBI group were decreased significantly at 6 h and 12 h(P<0.05),the r-ADC was not decreased significantly at 1 h(P>0.05)and decreased significantly at 6 h and 12 h(P<0.05).At each time point,there was no significant difference in rs-SWI(P>0.05).The area of mismatch between rs-SWI and rs-DWI was the most obvious at 6 h and 12 h,and the area of mismatch was decreased in size after treatment with AQP4-RNAi.There was no significant difference between TBI group and placebo group(P>0.05).In two groups,similar pathological changes were observed,which was depicted as vasogenic edema predominantly at 1 h and mixed edema at 6 h and 12 h. In RNA interference group,intracellular edema was markedly reduced at 6 h and 12 h,and the vasogenic edema was relieved to some extent at 12 h.Conclusion The treatment with APQ4-RNAi markedly alleviates cerebral edema.MM-MRI can reflect its pathological changes.The area of mismatch between SWI and DWI can prompt early detection of traumatic penumbra,which may provide useful information for clinical treatment.
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OBJECTIVE:To provide the clinical departments with a reference for promoting rational drug use. METHODS:The inpatient prescriptions given by orthopaedics and burn departments from Jun. to Dec. 2013 were selected randomly. The number of the selected prescriptions by each department accounted for 2% of the total prescriptions given by the corresponding department in that month,including 4 921 cases by orthopaedics department and 1 391 cases by burn department. Statistical analysis of irrational prescriptions was made according to Chinese Pharmacopoeia,New Materia Medica,the package insert, and other relevant references. RESULTS:1 821 prescriptions given by orthopaedics department and 378 by burn department were found to be irrational,accounting for 37.00% and 27.17% respectively. The reasons of irrationality mainly included im-proper compatibility,improper route of administration,contraindication in and use with caution by the elderly and children,re-peated drug use,improper drug combination etc. CONCLUSIONS:The system of prescription review should be strengthened, and clinical staff training system and pharmaceatical knowledge information platform are established to promote rational use of drugs.
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The paper analyzes the current status and existing problems of citation retrieval work, puts forward the design principle, overall structure and function of cited references integration tools, demonstrates the key technologies of system realization.An integrated retrieval platform for online literature citations is constructed for the following functions:one-stop retrieval of various citation databases, automatic removal of duplications, so as to reduce the burden of staffs and improve efficiency effectively.
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After an overall introduction of the novel functions of the CMCI institutional knowledge version developed by Medical Library of Chinese PLA , its coverage of institutions, authors, funds, journals and literature was de-scribed in terms of RDE semantics.The contents in literature were mined and analyzed in depth based on the litera-ture-marked information with the institutions database, funds database, journals database and literature database as their cores, the association of information resources in biomedical field was thus realized.The CMCI institutional knowledge version can be used to search published papers and citations, write citation reports, enforce bibliometric visualization analysis, issue different top-ranked statistical data, push associated information, increase institutional literature management modules, and provide personal literature management and assessment service for different in-stitutions.
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An integrated retrieval platform for online biomedical literature citations with the functions of one-stop retrieval, automatic removal of duplications, automatic grouping, and rapid output of standard citation report, was constructed on the basis of CMCI, with the C/S structure as its model and the NET framework as its development platform, in order to solve the problems of different citation databases in our library, such as inconsistent retrieval methods, inconsistent displaying methods of retrieval outcomes, and non-standard citation description, which can thus improve the efficiency of searching and citing biomedical literature.
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After a description of the performance assessment systems in domestic and foreign libraries, the personal performance assessment system was designed according to the annual target and key performance indicators worked out for the Database R&D Section in Medical Library of Chinese PLA and its problems existed at present.Imple-mentation of the system showed that it could arouse the enthusiasm of staff, increase the number of products, im-prove the quality of products , and guarantee the realization of annual target in our section .
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The data production and management processes were described and the factors influencing the data pro-cessing quality were analyzed with CMCC/CMCI as an example, and measures were put forward for improving the data production and management-the key to database development.
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Objective To reveal the research trends and hotspots of China's liver neoplasms literature from 2005 to 2010. Methods A bibliometric analysis was made based on the results of retrieving from the Chinese Medical Citation Index (CMCI). Results The number of China' s liver neoplasms literature increased regularly in the last 5 years. The fund articles accounted for 30% of total articles. This paper reports the highly cited articles, authors, institutions and journals. The top 5 provinces of publishing articles are Guangdong, Shanghai, Jiangsu, Shandong and Beijing. There are some major aspects of liver neoplasms research, such as treatment modalities, analysis of causes of disease, evaluation after radiation therapy, and experimental research. 3-dimensional conformal radiotherapy, radiofrequency ablation and chemoembolization have been becoming research hotspots. Conclusions The researches on liver neoplasms have been widely and deeply developing in China. A lot of research progresses were made. As the higher mortality of liver neoplasms, the research of comprehensive treatment is to be the further trend.
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Objective To observe the curative effect of refractory ascites with ascitic ultrafiltration and reinfusion into abdominal cavity.Methods Thirty-seven patients diganosed as refractory ascites were given ultrafiltration and reinfusion into abdominal cavity.The following parameters were detected respectively:24h urine volume,abdomen circumference,heart rate,blood pressure,serum electrolytes,serum albumin,total serum bilirubin.Results After treatment,the 24h urine volume increased and abdomen circumference decreasd significantly (P ＜ 0.01 ).There was no significant difference in heart rate,blood pressure,serum electrolytes,serum albumin and total serum bilirubin before and after treatment (P ＞0.05).Conclusion Ascitic ultrafiltration and reinfusion into abdominal cavity has some effects on refractory ascites.