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1.
Journal of Korean Medical Science ; : 201-206, 2011.
Artigo em Inglês | WPRIM | ID: wpr-123290

RESUMO

The objective of this study was to evaluate the prevalence of asthma, allergic rhinitis, and atopic dermatitis, as well as the risk factors of wheezing among young adults in the Korean military. Young military conscripts in five areas completed a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. For subjects with current wheeze in one sample area, baseline spirometry and bronchodilator response were measured. For subjects without a significant response to bronchodilator (improvement in FEV1 of more than 200 mL and 12%), methacholine challenge tests (MCT) were also performed. Of 3,359 subjects that completed the questionnaire, 354 (10.5%) had current wheeze, 471 (14.0%) had current allergic rhinitis, and 326 (9.7%) had current eczema. Current wheeze was associated with family history of allergic disease, overweight, current smoking, allergic rhinitis, and atopic dermatitis. Of 36 subjects with current wheeze who underwent PFT with or without MCT in the Anyang area, 24 (66.7%) were confirmed to have current asthma. In conclusion, the prevalence of allergic disease in young adults of Korean military is not low, and the risk factors of wheezing include family history of allergic disease, overweight, current smoking, allergic rhinitis, and atopic dermatitis.


Assuntos
Adulto , Humanos , Adulto Jovem , Asma/complicações , Testes de Provocação Brônquica , Hipersensibilidade/epidemiologia , Militares , Prevalência , Inquéritos e Questionários , República da Coreia/epidemiologia , Testes de Função Respiratória , Sons Respiratórios/etiologia , Fatores de Risco
2.
Korean Journal of Legal Medicine ; : 51-60, 2000.
Artigo em Coreano | WPRIM | ID: wpr-38112

RESUMO

The validation study for two STR loci on X-chromosome, DXS7132 and GATA31D10, was done including allelic distribution and frequency of each allele to use these results for individual identification and paternity testing. For 496 unrelated Koreans, above two STR loci were amplified simultaneously using duplex PCR amplification method. The amplified products were analyzed by polyacrylamide gel electrophoresis followed by silver staining. In male DXS7132 locus revealed 7 different alleles ranging from 276bp to 300bp. The largest allele was consisted of 14 repetition of [TCTA] unit and took 0.3417. The allele 15 followed next as 0.3165 and allele 13 as 0.1726. In female general distribution was same except one allele, allele 18 was found additionally. The heterozygosity was 0.7706 and 23 different genotypes were found. Polymorphism information content(PIC) was 0.727. Two cases of mutation were noted in DXS7132 locusIn both male and female 7 different alleles were noted in GATA31D10 locus and the alleles ranged from 195bp to 231bp. The allele 15(199bp) took the majority of all as 0.825. The other alleles showed rather relatively low frequency. The heterozygosity was 0.2385 and 11 different genotypes were found. PIC was 0.2521, and no mutation was noted in GATA31D10 locus. Considering these two loci together, 22 different halpotype were noted.


Assuntos
Feminino , Humanos , Masculino , Alelos , Eletroforese em Gel de Poliacrilamida , Genótipo , Haplótipos , Paternidade , Reação em Cadeia da Polimerase , Coloração pela Prata
3.
Korean Journal of Dermatology ; : 468-474, 1999.
Artigo em Coreano | WPRIM | ID: wpr-52589

RESUMO

BACKGROUND: Atopic dermatitis, characterized by dry, flasky, easily irritated skin, is the most common form of dermatitis seen during childhood. Infants with atopic dermatitis and other eczematous conditions need special dermatologic care to hydrate their skin and to minimize contact with irritants or allergens. OBJECTIVE: The purpose of our study is to evaluate the safety and efficacy of the skin products developed for children. METHODS: Twenty-eight normal children and 26 children with atopic dermatitis were evaluated clinically after using following commercal skin products : (lotion, cream, shampoo, soap, face wash wash) for 2 weeks. Water content of the skin of 14 volunteers was measured serialy over 8 haurs at 2 hour intervals after the application of each skin product. The skin pH of 16 volunteers was also measured serialy over 60 minutes at 30 minute intervals after application. We performed visual skin erythema grading, skin erythema grading by dermaspectrometer, transepidermal water loss measurement, skin water content measurement, and keratinocyte morphology observation by D-squame after the application of the skin products to 13 volunteers for 4 days.


Assuntos
Criança , Humanos , Lactente , Alérgenos , Carcinoma Basocelular , Carcinoma de Células Escamosas , Dermatite , Dermatite Atópica , Eritema , Concentração de Íons de Hidrogênio , Irritantes , Queratinócitos , Ceratose Seborreica , Pele , Sabões , Voluntários
4.
Korean Journal of Dermatology ; : 495-499, 1999.
Artigo em Coreano | WPRIM | ID: wpr-52586

RESUMO

BACKGROUND: Defective adhesion and migration of melanocyte may be involved in pathogenesis of vitiligo. Tenascin, a glycoprotein of the extracellular matrix, has a role in cell adhesion and migration. It has been reported that abundant expression of tenascin in vitiligo lesion may inhibit melanocyte adhesion and migration. OBJECTIVE: To investigate the tenascin expression in vitiligo skin lesions and to compare with clinical findings. METHODS: We studied 9 patients with vitiligo. The expressions of tenascin were studied by immunahistochemieal techniques.


Assuntos
Humanos , Adesão Celular , Matriz Extracelular , Glicoproteínas , Melanócitos , Pele , Tenascina , Vitiligo
5.
Journal of Korean Orthopaedic Research Society ; : 111-116, 1999.
Artigo em Coreano | WPRIM | ID: wpr-69892

RESUMO

The use of interlocking intramedullary nail is accepted one of treatment choices in the comminuted fractures of humeral shaft. The insertion of distal interlocking screws remains technically problematic. The use of intrageon's hands during the procedure. In order to reduce technical difficulty and radiation exposure, it is necessary to compare the rigidity of intramedullary nail according to the number of distal interlocking screws. The purpose of study is to compare the stability of interlocking intramedullary nail according to the number of distal screws by means of torsional compliance measurements in the simulated humeral shaft fractures. Simulated fractures were made in 20 humora from 10 cadavera at the mid-junction of humeral shaft. All humora were fixated with titaium humeral nail system. Interlocking screws were placed at proximal and distal screw holes by standard procedure. Group I consisted of 10 humora fixated with one distal interlocking screw and group II consisted of 10 humora fixated with two distal intterlocking screws. Torsional compliance was measured with single-end of 10 humora fixated with two distal interlocking screws. Torsional compliance was measured with single-end double arm torquing machine. The torsional compliance analog was 0.0294+/-0.0033 mm/N mm for one screw and 0.0241+/-0.0045 mm/N mm for two distal screws. The torsional compliance analog between two groups was found to be statistically insignificant(p=0.23). In conclusion, One distal interlocking screw was not inferior to two interlocking screws in terms of biomechanical characteristics, especially torsional compliance analog.


Assuntos
Braço , Complacência (Medida de Distensibilidade) , Fixação Intramedular de Fraturas , Fraturas Cominutivas , Mãos
6.
Korean Journal of Dermatology ; : 676-678, 1999.
Artigo em Coreano | WPRIM | ID: wpr-169764

RESUMO

Relapsing polychondritis is a rare inflammatory disorder affecting the cartilaginous structures throughout the body. Although there is no pathognomonic laboratory tests, clinical features, when coupled with histopathologic findings, enable one to make a diagnosis of relapsing polychondritis. A 26-year-old man presented with purplish, swollen, and tender auricles and injected eyes. His symptoms had developed eight months ago and fluctuated irrespective of various medications such as corticosteroids and antibiotics. Histopathologic examination revealed loss of basophilic staining of the cartilage with some dissolution of its structures. Treatment was initiated with dapsone, However, the remission was too immediate to be considered as a effect of dapsone.


Assuntos
Adulto , Humanos , Corticosteroides , Antibacterianos , Basófilos , Cartilagem , Dapsona , Diagnóstico , Policondrite Recidivante
7.
Korean Journal of Dermatology ; : 1037-1042, 1998.
Artigo em Coreano | WPRIM | ID: wpr-35784

RESUMO

BACKGROUND: Vitiligo is an acquired depigmentary disorder of the skin and hair. The etiology is unknown, however an autoimmune hypothesis is favored. OBJECTIVE: We performed this study to develop a better understanding of the clinical features of vitiligo patients. METHOD: We evaluated clinical manifestations of 1203 vitiligo patients(556 males and 647 females). RESULTS AND CONCLUSIONS: 1. The mean age of onset and that of the first visits made by patients were 22.9+/-18 and 27.9+/-19 years, respectively. 2. The face(37.4%) was the most common site of initial involvement. In decreasing order of frequency, the common sites of involvement were the face and neck(65.9%), thorax and abdomen(42.9%), upper extremities(42.3%). 44.5% of the cases had the vulgaris type, 26.1% the focal type, and 21.1% the segmental type. During the three months before a visit, 44% of patients experienced progression of disease. Within one year, about 75% of patients reported that the disease had progressed. 3. Precipitating or aggravating factors such as trauma(13.1%), psychological stress(9.2%), sun light (2.8%) and pregnancy(2.5%), were found in 30.9% of patients. Thyroid disease was the most common associated disease.


Assuntos
Humanos , Masculino , Idade de Início , Cabelo , Pele , Sistema Solar , Tórax , Doenças da Glândula Tireoide , Vitiligo
8.
Annals of Dermatology ; : 147-152, 1998.
Artigo em Inglês | WPRIM | ID: wpr-49670

RESUMO

BACKGROUND: Ultraviolet(UV) light is one of the injurious environmental agents which is known to lead to apoptosis of cells. However, studies on UVB-induced apoptosis of melanocytes are still lacking and there are some discrepancies between researchers. OBJECTIVE: Our purpose was to evaluate the characteristics of UVB-induced apoptosis of melanocytes and G361 cells. METHODS: Cultured normal human melanocytes and malignant melanoma cell lines (G361 cells) were analyzed by several detection methods including morphological examination of propidium iodide(PI) stained cells under fluorescence microscopy, quantitation of fragmented DNA, and flow cytometric analysis. RESULTS: Both melanocytes and G361 cells showed similar rate of apoptosis with gradual increment of UVB doses by the quantitation of fragmented DNA. However, flow cytometric analysis using scatter properties and PI stainability revealed that the melanocytes were more resistant to UVB than G361 cells. CONCLUSION: We suggest that melanocytes seem to be more resistant to UVB-induced injury than G361 cells. In addition, various methods for the detection of apoptosis might be necessary for its study. (Ann Dermatol 10:(3) 147152, 1998).


Assuntos
Humanos , Apoptose , Linhagem Celular , DNA , Melanócitos , Melanoma , Microscopia de Fluorescência , Propídio
9.
Korean Journal of Medical Mycology ; : 77-80, 1997.
Artigo em Coreano | WPRIM | ID: wpr-166473

RESUMO

Superficial fungal infections of the face, especially at the beard region, are frequently misdiagnosed. Application of corticosteroids modifies these original clinical manifestations and induces other dermatoses, which may lead to misdiagnosis. We report the case of a patient with fungal folliculitis on the face. The patient had multiple papules and pustules on the perioral area, cheek and periorbital area. Clinically, these lesions looked like lupus miliaris disseminatus faciei or rosacea. At first, we treated the patient with systemic roxithromycin and topical clindamycin, but there was no response to the therapy. Histopathological and mycological examinations revealed that the diagnosis was folliculitis due to Trichophyton mentagrophytes. The lesion was cured by administration of itraconazole for 6 weeks.


Assuntos
Humanos , Corticosteroides , Bochecha , Clindamicina , Diagnóstico , Erros de Diagnóstico , Foliculite , Itraconazol , Rosácea , Roxitromicina , Dermatopatias , Trichophyton
10.
Annals of Dermatology ; : 246-252, 1997.
Artigo em Inglês | WPRIM | ID: wpr-178705

RESUMO

BACKGROUND: It was demonstrated that ultraviolet(UV) B light induces the release of IL-1α in cultured human epithelial cell line and augmentation of GM-CSF production by UVB is reported to be mediated by IL-1α in the murine keratinocyte cell line Pam 212. OBJECTIVE: The purpose of this study was to evaluate the effects of UVB on kinetic profile of IL-1 and GM-CSF mRNA expression and to see whether synthesis of GM-CSF by UVB can be completely inhibited by blocking IL-1α mediated pathway. METHODS: We used a competitive RT-PCR for measuring cytokine gene expression in epithelial cell line after UV radiation. RESULTS: The IL-1α mRNA increased as early as 1h after UV irradiation, and then decreased at 3h after the irradiation. Thereafter, the response of IL-1α mRNA was upregulated with a second peak at 6h after the UV irradiation. However, mRNA for GM-CSF increased at 1h after UV light exposure and anti-IL-1α antibodies could only partially inhibit UV-augmented GM- CSF production. CONCLUSION: UVB induced GM-CSF production seemed to be mainly mediated by UVB induced IL-1α but these results suggest that UVB may also induce GM-CSF production through an IL-1α independent pathway.


Assuntos
Humanos , Anticorpos , Linhagem Celular , Células Epiteliais , Expressão Gênica , Fator Estimulador de Colônias de Granulócitos e Macrófagos , Interleucina-1 , Queratinócitos , RNA Mensageiro , Raios Ultravioleta , Regulação para Cima
11.
Annals of Dermatology ; : 182-187, 1997.
Artigo em Inglês | WPRIM | ID: wpr-87320

RESUMO

BACKGROUND: Oculocutaneous albinism (OCA) is a genetic disorder of the melanin pigment system in which melanin synthesis is reduced or absent in the skin, hair, and eyes. OCA is classified into two major types, and tyrosinase-related OCA can be produced by mutations of the structural gene for tyrosinase enzyme (TYR gene). OBJECTIVE: The purpose of this study was to analyze the segregation of mutant alleles of the TYR gene in tyrosinase-negative and tyrosinase-positive Korean OCA patients and families. METHODS: We amplified exon I, II, and III of the TYR gene of Korean OCA patients and their families by polymerase chain reactions (PCR), and analyzed the mutations by restriction fragment length polymorphism (RFLP) analysis in exon I and single-strand conformation polymorphism (SSCP) analyses in exon II and exon III. RESULTS: Two tyrosinase-negative cases showed mutations in exon I. Four tyrosinase-nega-tive cases and one tyrosinase-positive case showed mutations in exon II, and one tyrosinase-neg- ative case showed mutations in exon III. In summary, we found three kinds of mutation in four tyrosinase-negative OCA patients and one tyrsinase-positive OCA patient. CONCLUSIONS: RFLP and SSCP analysis can provide a basis for a rapid and sensitive screening system to detect TYR gene mutations of Korean OCA patients and their families.


Assuntos
Humanos , Albinismo Oculocutâneo , Alelos , Éxons , Cabelo , Coreia (Geográfico) , Programas de Rastreamento , Melaninas , Monofenol Mono-Oxigenase , Reação em Cadeia da Polimerase , Polimorfismo de Fragmento de Restrição , Polimorfismo Conformacional de Fita Simples , Pele
12.
Korean Journal of Dermatology ; : 902-908, 1997.
Artigo em Coreano | WPRIM | ID: wpr-222936

RESUMO

BACKGROUND: The skin shows many physiological changes during pregnancy. Although these physiological skin changes do not usually impair the health of the mother or the fetus, some can be cosmetically significant and of importance to the dermatologist. OBJECTIVE: The aim of our study was to determine the incidence and clinical findings of these skin changes during pregnancy. METHODS: We made a prospective study of 157 women in the third trimester of pregnancy who visited the prenatal care clinic at Seoul National University Hospital from January 1996 to June 1996. Women with pathological pregnaneies were excluded. RESULTS: The results of the study are summarized as follows. 1. Various skin changes occurred such as pigmentary alteration, vascular changes, striae, abnormalities in hair growth, and nail changes. In all subjects, one or more of these changes were found. 2. The incidence of hyperpigmentation was highest among the skin changes. The incidence of hyperpigmentation of areola and nipple was 100%. Linea nigra were observed in 81.5%. 3. Palmar erythema, suprapubic hirsutism, and abdominal striae were observed in 36.3%, 14.0%, and 40.1 %, respectively. CONCLUSION: Physiological skin changes during pregnancy were various and observed with high frequency. The incidences of vascular changes, hair and nail changes in Korean pregnant women were reported for the first time.


Assuntos
Feminino , Humanos , Gravidez , Gravidez , Eritema , Feto , Cabelo , Hirsutismo , Hiperpigmentação , Incidência , Mães , Mamilos , Terceiro Trimestre da Gravidez , Gestantes , Cuidado Pré-Natal , Estudos Prospectivos , Seul , Pele
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