Neuroimaging advances in the studies on cognitive dysfunction in patients with end-stage renal disease / 西安交通大学学报(医学版)

End-stage renal disease (ESRD) is the serious outcome of chronic kidney disease. ESRD patients need dialysis or kidney transplantation to sustain life. According to epidemiological investigations, ESRD patients generally have cognitive dysfunction, which is one of the key problems affecting patients' quality of life. In this paper, the potential relationship among ESRD, brain structure and function, and cognitive function is described based on magnetic resonance imaging technology in ESRD patients. This paper points out that the key problem to be solved is to predict cognitive outcome based on imaging markers.

Brain-based Correlations Between Psychological Factors and Functional Dyspepsia

BACKGROUND/AIMS: Increasing evidence shows involvement of psychological disorders in functional dyspepsia (FD), but how psychological factors exert their influences upon FD remains largely unclear. The purpose of the present study was to explore the brain-based correlations of psychological factors and FD. METHODS: Based on Fluorine-18-deoxyglucose positron emission tomography-computed tomography, the altered cerebral glycometabolism was investigated in 40 FD patients compared with 20 healthy controls during resting state using statistical parametric mapping software. RESULTS: FD patients exhibited increased glucose metabolism in multiple regions relative to controls (P < 0.001, family-wise error corrected). After controlling for the dyspeptic symptoms, increased aberrations persisted within the insula, anterior cingulate cortex (ACC), middle cingulate cortex (MCC) and middle frontal cortex (midFC), which was related to anxiety and depression score. Interestingly, FD patients without anxiety/depression symptoms also showed increased glycometabolism within the insula, ACC, MCC and midFC. Moreover, FD patients with anxiety/depression symptoms exhibited more significant hypermetabolism within the above 4 sites compared with patients without anxiety/depression symptoms. CONCLUSIONS: Our results suggested that the altered cerebral glycometabolism may be in a vicious cycle of psychological vulnerabilities and increased gastrointestinal symptoms.