[B and T lymphocyte and subsets in the peripheral blood in vitiligo patients]

Background: vitiligo is a dermatological disorder characterized by destruction of melanocytes and loss of pigmentation. The cause of vitiligo is not known. It has been suggested that immune mechanisms may be involved. In the present study, we evaluate B and T lymphocyte and subsets in the peripheral blood in vitiligo

Materials and methods: 36 patients suffering from vitiligo disease [23 of patients with active vitiligo and 13 of patients with stable vitiligo] and 22 persons as control were studied respectively for different immunological parameters such as: T Cell [CD[2]], Bcell [CD[19]], T [CD[4]], T [CD[8]], CD[4] / CD[8] ratio in the peripheral blood. The flow cytometry were used for determination of lymphocyte and subsets

Results: we have shown a decrease of B cell and T[CD[8]] cell with an increase of CD[4] / CD[8] ratio in the active vitiligo patients as compared to control. In the stable vitiligo patients, only T[CD[8]] cell is decreased, [p<0.05]

Conclusions: thus, our data show aberrations for lymphocyte and subsets in active vitiligo than stable vitiligo.we suggest that immune response, especially cell mediated immunity may play a important role in the pathogenesis of the disease

Seroepidemiology assay of toxoplasmosis in infants who were confined to bed in infants ward of Taleghani hospital during 1379-1380

As some of the mortality and morbidity of infants who are less than one year, is related to contamination with Toxoplasma gondii parasite during fetal time, the aim of this survey is to study the prevalence of Toxoplasmosis in infants visiting Taleghani medical center during 1379-1380. In this survey the sera of 106 and 104 newborn infants from 1 day to 1 month who were suspected to congenital Toxoplasmosis and were hospitalized in Infantile ward of Taleghani hospital were evaluated for IgM and IgG specific antibodies with ELISA and IFA techniques, respectively. According to the results of IFA technique, if the 1/100 is the minimum titer for specific Ig M antibody against Toxoplasmosis, 5 infants were positive and if 1/200 is the minimum titer for specific Ig G antibody against Toxoplasmosis, 41 infants were positive. 6 infants had specific Ig M antibody and 38 infants had specific IgG antibody against Toxoplasmosis by ELISA technique. As a whole, 6 infants [5.66%] were positive which were suggested congenital Toxoplasmosis. With deletion of 6 infected infants, the prevalence of chronic Toxoplasmosis between the mother whose infant was confined in Taleghani hospital was 34 percent by IFA and 30.2 percent by ELISA technique

[Seroepidemiology assay of toxoplasmosis in infants who was confined to bed in infants ward of Taleghani hospital during 1379-1380]

Background: As some of the mortality and morbidity of infants who are less than one y ear, is related to contamination with Toxoplasma gondii parasite during fetal time, the aim of this survey is to study the prevalence Toxoplasmosis in infants visited Taleghani medical center during 1379-1380

Materials and methods: In this survey the sera of 106 and 104 newborn infants from 1 day to 1 month who were suspected to congenital Toxoplasmosis and were hospitalized in Infantile ward of Taleghani hospital were evaluated for lgM and lgG specific antibodies with ELISA and IFA techniques, respectively

Results: According to the results of IFA technique, if the 1/100 is the minimum titer for specific lg M antibody against Toxoplasmosis, 5 infants were positive and if 1/200 is the minimum titer for specific lgG antibody against Toxoplasmosis, 41 infants were positive. 6 infants had specific lg M antibody and 38 infants had specific lgG antibody against Toxoplasmosis by ELISA technique

Conclusions: As a whole, 6 infants [5.66%] were positive which were suggested congenital Toxoplasmosis. With deletion of 6 infected infants, the prevalence of chronic Toxoplasmosis between the mother whose infants was confined in Taleghani hospital was 34 percent by IFA and 30.2 percent by ELISA technique