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Journal of Central South University(Medical Sciences) ; (12): 1166-1170, 2009.
Artigo em Inglês | WPRIM | ID: wpr-814177

RESUMO

OBJECTIVE@#To investigate the association between transforming growth factor beta1(TGF-beta1)-800G>A polymorphism and cerebral infarction (CI).@*METHODS@#The genotypes of 247 patients with atherosclerotic cerebral infarction and 167 sex- and age-matched healthy controls were detected by PCR-RFLP, and the frequency distribution of alleles calculated.@*RESULTS@#TGF-beta1-800G>A polymorphism was found in Han population in Hunan Province, China. The distribution of -800G>A genotypes was consistent with Hardy-Weinberg balance in the CI and healthy control group. There was no significant difference between genotypes and allele frequency of TGF-beta1-800G>A in the CI and control group (P>0.05). Logistic regression analysis suggested that no genotypes could increase or reduce the risk of CI onset (P>0.05).@*CONCLUSION@#TGF-beta1-800G>A polymorphism is not associated with CI in Han population in Hunan Province.


Assuntos
Feminino , Humanos , Masculino , Estudos de Casos e Controles , Infarto Cerebral , Genética , China , Etnologia , Frequência do Gene , Genótipo , Polimorfismo Genético , Genética , Polimorfismo de Nucleotídeo Único , Fator de Crescimento Transformador beta1 , Genética
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