RESUMO
Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium induced hypnosis in rats after intermittent aerosol spray inhalational exposure, for 1/2 hour daily for 7 consecutive days, compared to the saline control group. Further, ED50 +/- SEM value for haloperidol induced catalepsy, CD50 +/- SEM value for pentylenetetrazole induced seizure and CI50 +/- SEM value for electroshock (i.e. the dose of haloperidol, PTZ and intensity of electroshock producing catalepsy or positive seizure response in 50% of rats) were significantly decreased after 7 days exposure to oxydemeton-methyl compared to that of saline control group. The study has established the central nervous system depressant effect, extrapyramidal effect and proconvulsant potential of oxydemeton-methyl which is widely used by the agricultural workers in the form of field spray.
Assuntos
Animais , Antipsicóticos/toxicidade , Barbital/farmacologia , Comportamento Animal/efeitos dos fármacos , Catalepsia/induzido quimicamente , Convulsivantes , Eletrochoque , Comportamento Exploratório/efeitos dos fármacos , Feminino , Haloperidol/toxicidade , Hipnóticos e Sedativos/farmacologia , Inseticidas/toxicidade , Masculino , Sistema Nervoso/efeitos dos fármacos , Compostos Organotiofosforados/toxicidade , Pentilenotetrazol , Ratos , Ratos Sprague-Dawley , Convulsões/induzido quimicamente , Sono/efeitos dos fármacos , Fatores de TempoRESUMO
Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium-induced hypnosis after intermittent aerosol spray inhalational exposure for 1 h in rats compared to the saline control group. Further, CD50 +/- S.E.M. value for pentylenetetrazole (PTZ) and CI50 +/- S.E.M. value for electroshock (i.e. the dose of PTZ and intensity of electroshock producing positive seizure response in 50% of rats) were significantly decreased by acute exposure to oxydemeton-methyl compared to that of saline control group. The study has established the central nervous system depressant effect and proconvulsant potential of oxydemeton-methyl which is widely used by the agricultural workers in the form of field spray.